Featured Research

from universities, journals, and other organizations

Impaired activity of the protein MTOR a strain on the heart

Date:
July 19, 2010
Source:
Journal of Clinical Investigation
Summary:
New research in mice suggests that drugs that inhibit the protein MTOR, which are used to treat several forms of cancer, might have adverse effects on heart function in patients with ongoing heart dysfunction.

A team of researchers, led by Gianluigi Condorelli, at the University of California San Diego, La Jolla, has generated data in mice that suggest that drugs that inhibit the protein MTOR, which are used to treat several forms of cancer, might have adverse effects on heart function in patients with ongoing heart dysfunction.

Related Articles


In the study, it was found that adult mice lacking MTOR in their heart muscle cells developed a fatal heart condition. Disease was associated with accumulation of the protein 4E-BP1, which is an inhibitor of protein generation that is normally held in check by a protein complex containing MTOR. Further analysis indicated that in a model of high blood pressure the mice lacking MTOR in their heart muscle cells developed heart failure more quickly than did normal mice. Importantly, deletion of 4E-BP1 under these conditions improved heart function and survival.

Thus, decreased MTOR activity impairs the protective heart response to stress, by enhancing 4E-BP1 activity, providing a potential new therapeutic strategy for improving heart function in patients with heart failure and a warning to clinicians using MTOR inhibitors.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhang et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI43008

Cite This Page:

Journal of Clinical Investigation. "Impaired activity of the protein MTOR a strain on the heart." ScienceDaily. ScienceDaily, 19 July 2010. <www.sciencedaily.com/releases/2010/07/100719124402.htm>.
Journal of Clinical Investigation. (2010, July 19). Impaired activity of the protein MTOR a strain on the heart. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2010/07/100719124402.htm
Journal of Clinical Investigation. "Impaired activity of the protein MTOR a strain on the heart." ScienceDaily. www.sciencedaily.com/releases/2010/07/100719124402.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins