Featured Research

from universities, journals, and other organizations

Nanoparticles plus adult stem cells demolish plaque, study finds

Date:
July 21, 2010
Source:
American Heart Association
Summary:
A technique that combines nanotechnology with adult stem cells appears to destroy atherosclerotic plaque and rejuvenate the arteries, according to a new study.

A technique that combines nanotechnology with adult stem cells appears to destroy atherosclerotic plaque and rejuvenate the arteries, according to a study reported at the American Heart Association's Basic Cardiovascular Sciences 2010 Scientific Sessions -- Technological and Conceptual Advances in Cardiovascular Disease.

In the study, nanoparticles (microscopic particles with at least one dimension less than 80 nm) were infused into the heart of pigs along with adult stem cells. After the nanoparticles were heated by laser light, they burned away arterial plaque. However, nanoparticles were less effective at eliminating plaque if not combined with adult stem cells.

"This unique approach holds promise for use in humans for acute care and urgent restoration of blood flow," said Alexandr Kharlamov, M.D., lead author and research manager at the Department of Internal Medicine and Research Center of Regenerative Medicine, Ural State Medical Academy in Yekaterinburg, Russian Federation. "Biophotonics (light therapy), plasmonics (plasma therapy), stem cell therapy and nanotechnology might someday offer a completely novel treatment to reduce artery plaque build-up."

Unlike angioplasty, a common treatment for atherosclerosis, this new technique seems to actually demolish the plaque, Kharlamov said. In angioplasty, a balloon-tipped catheter is threaded into a blocked artery and the balloon is inflated to restore blood flow. The balloon squeezes plaque against the artery wall, but does not eliminate it.

A treatment group of 19 pigs received silica-gold nanoshells, while 18 animals in a control group received saline solution. The treatment group was subdivided into three subsets that received nanoparticles in one of three ways:

  • intracellularly along with adult stem cells infused into the heart;
  • via an infusion of gas-filled, protein-coated microbubbles that contained no stem cells; or
  • delivered through a bioengineered patch that also contained adult stem cells and was attached to the artery itself through minimally invasive surgery.

The researchers found that plaque volume shrunk considerably in the nanoparticle groups immediately after the procedure (an average of 28.9 percent across the three groups) and six months later plaque volume had declined 56.8 percent on average. In the control group that received only saline, plaque volume increased an average of 4.3 percent, he said.

The greatest reductions in plaque volume occurred in the treatment groups that received stem cells in addition to the nanoparticles. Also, both groups that received stem cells showed signs of new blood vessel growth (neovascularization) and restoration of artery function.

Three cases of blood clots occurred only in the microbubble treatment group, Kharlamov said.

"Nanoburning in combination with stem cell treatment promises demolition of plaque and functional restoration of the vessel wall," Kharlamov added.

The study was funded by private investors and the Research Center of Regenerative Medicine, Ural State Medical Academy, Yekaterinburg, Russia.

Co-authors are: Jan Gabinsky, M.D., Ph.D., head of research team and Alexandr Perrish, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Nanoparticles plus adult stem cells demolish plaque, study finds." ScienceDaily. ScienceDaily, 21 July 2010. <www.sciencedaily.com/releases/2010/07/100719215830.htm>.
American Heart Association. (2010, July 21). Nanoparticles plus adult stem cells demolish plaque, study finds. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/07/100719215830.htm
American Heart Association. "Nanoparticles plus adult stem cells demolish plaque, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/07/100719215830.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins