Featured Research

from universities, journals, and other organizations

Functional magnetic resonance imaging to evaluate pancreatic cancer

Date:
July 30, 2010
Source:
World Journal of Gastroenterology
Summary:
In an effort to develop new therapies for pancreatic cancer, models of this disease must be created and characterized. A recent study from United States found that advanced magnetic resonance imaging methods could be used to differentiate living from dead tumor cells in a rabbit model of pancreatic cancer, thus providing a more in-depth understanding of this model of pancreatic cancer as well as the imaging methods employed.

Pancreatic ductal adenocarcinoma (the disease commonly referred to as pancreatic cancer) carries the worst prognosis of any cancer. As current treatments offer minimal benefit, entirely new approaches are needed.

Given the success of local therapies, as opposed to intravenous systemic therapies, for liver diseases (such as hepatocellular carcinoma), it is thought that similar local therapies may benefit patients with pancreatic cancer. To develop such therapies, it would be useful to devise targets that are easy to obtain and can indicate the efficacy of these new therapies in models of pancreatic cancer.

This research, led by Dr. Robert Lewandowski and colleagues at Northwestern University's Feinberg School of Medicine and recently published on July 14, 2010 in the World Journal of Gastroenterology, addresses this need. Using a rabbit model of pancreatic cancer that allows for arterial catheterization, the authors aimed to test the hypotheses that advanced functional magnetic resonance imaging (MRI) could be used to assess regional differences in tumor function in this model. It was found that the two types of functional MRI studied (diffusion-weighted MRI and transcatheter intraarterial perfusion MRI) could be used to differentiate living tumor cells from dead tumor cells and thus can be used to assess tumor viability.

Numerous models of pancreatic cancer currently exist, but this research is the first to assess functional MRI in the VX2 rabbit model of pancreatic cancer studied in this work. Using these findings, it may be possible in the future to assess therapeutic efficacy in this animal model using functional MRI as opposed to more invasive techniques such as biopsy or necropsy.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lewandowski RJ, Eifler AC, Bentrem DJ, Chung JC, Wang D, Woloschak GE, Yang GY, Ryu R, Salem R, Larson AC, Omary RA. Functional magnetic resonance imaging in an animal model of pancreatic cancer. World Journal of Gastroenterology, 2010; 16 (26): 3292 DOI: 10.3748/wjg.v16.i26.3292

Cite This Page:

World Journal of Gastroenterology. "Functional magnetic resonance imaging to evaluate pancreatic cancer." ScienceDaily. ScienceDaily, 30 July 2010. <www.sciencedaily.com/releases/2010/07/100730091003.htm>.
World Journal of Gastroenterology. (2010, July 30). Functional magnetic resonance imaging to evaluate pancreatic cancer. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2010/07/100730091003.htm
World Journal of Gastroenterology. "Functional magnetic resonance imaging to evaluate pancreatic cancer." ScienceDaily. www.sciencedaily.com/releases/2010/07/100730091003.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) — A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com
Common Antibiotic Could Lead To Heart-Related Death

Common Antibiotic Could Lead To Heart-Related Death

Newsy (Aug. 20, 2014) — Danish researchers discovered patients taking clarithromycin have an increased risk of dying from a heart-related issue. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins