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Solving the mystery of bone loss from drug for epilepsy and bipolar disorder

Date:
August 6, 2010
Source:
American Chemical Society
Summary:
Scientists are reporting a possible explanation for the bone loss that may occur following long-term use of a medicine widely used to treat epilepsy, bipolar disorder, and other conditions. The drug, valproate, appears to reduce the formation of two key proteins important for bone strength.

Scientists are reporting a possible explanation for the bone loss that may occur following long-term use of a medicine widely used to treat epilepsy, bipolar disorder, and other conditions. The drug, valproate, appears to reduce the formation of two key proteins important for bone strength, they said. Their study, which offers a solution to a long-standing mystery, appears in ACS' Journal of Proteome Research.

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Glenn Morris and colleagues point out that use of valproate, first introduced more than 40 years ago for the prevention of seizures in patients with epilepsy, has expanded. Valproate now is prescribed for mood disorders, migraine headache, and spinal muscular atrophy (SMA), a rare genetic disease that causes loss of muscle control and movement. Many SMA patients develop weak bones as a result of the disease itself, making further bone loss from valproate especially undesirable. Doctors have known about the bone-loss side effect, but until now, there has been no molecular explanation.

In an effort to determine why bone loss occurs, the scientists profiled valproate's effects on more than 1,000 proteins in the cells of patients with SMA. They found that valproate reduced production of collagen, the key protein that gives bone its strength, by almost 60 percent. The drug also reduced levels of osteonectin, which binds calcium and helps maintain bone mass, by 28 percent. "The results suggest a possible molecular mechanism for bone loss following long-term exposure to valproate," the article notes.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fuller et al. Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells. Journal of Proteome Research, 2010; 100722144125012 DOI: 10.1021/pr1005263

Cite This Page:

American Chemical Society. "Solving the mystery of bone loss from drug for epilepsy and bipolar disorder." ScienceDaily. ScienceDaily, 6 August 2010. <www.sciencedaily.com/releases/2010/08/100804122713.htm>.
American Chemical Society. (2010, August 6). Solving the mystery of bone loss from drug for epilepsy and bipolar disorder. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2010/08/100804122713.htm
American Chemical Society. "Solving the mystery of bone loss from drug for epilepsy and bipolar disorder." ScienceDaily. www.sciencedaily.com/releases/2010/08/100804122713.htm (accessed March 6, 2015).

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