Featured Research

from universities, journals, and other organizations

New approaches could help defeat HIV

Date:
August 10, 2010
Source:
The Biochemical Society
Summary:
Drug resistance remains a major problem in combating HIV infection, but a different approach to drug development could be the answer. Current viral inhibitors target the HIV-1 protease function with a competitive mechanism. New research suggests that pharmaceutical companies look at compounds that use an allosteric non-competitive mechanism of inhibition.

Drug resistance remains a major problem in combating HIV infection, but a different approach to drug development could be the answer.

Current viral inhibitors target the HIV-1 protease function with a competitive mechanism. Writing in the BJ ChemBio Knowledge Environment of the Biochemical Journal, Max Chang and colleagues from the Scripps Research Institute, La Jolla, suggest that pharmaceutical companies look at compounds that use an allosteric non-competitive mechanism of inhibition.

The scientists examined 44 000 compounds that have already been shown to be effective at disrupting protein-protein and protein-nucleic acid interfaces and identified a compound which inhibits wild-type HIV-1 protease, as well as a drug-resistant form of protease.

Guy Salvesen, Vice Chair, The Americas, for the Biochemical Journal, said: "A major problem that plagues efficient pharmaceutical therapy is the poor selectivity of, and development of resistance to, drugs that target enzyme active sites. This approach represents a vast majority of drug development efforts for not only AIDS, but also for cancer and inflammatory diseases. The mindset of pharmaceutical chemists needs to be changed to explore more productive areas, and the paper by Max Chang and his colleagues provides a paradigm-shifting approach that, while still in its early days, would well be heeded by pharmaceutical companies."


Story Source:

The above story is based on materials provided by The Biochemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. MaxW. Chang, MichaelJ. Giffin, Rolf Muller, Jeremiah Savage, YingC. Lin, Sukwon Hong, Wei Jin, LandonR. Whitby, JohnH. Elder, DaleL. Boger, BruceE. Torbett. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochemical Journal, 2010; 429 (3): 527 DOI: 10.1042/BJ20091645

Cite This Page:

The Biochemical Society. "New approaches could help defeat HIV." ScienceDaily. ScienceDaily, 10 August 2010. <www.sciencedaily.com/releases/2010/08/100810082640.htm>.
The Biochemical Society. (2010, August 10). New approaches could help defeat HIV. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/08/100810082640.htm
The Biochemical Society. "New approaches could help defeat HIV." ScienceDaily. www.sciencedaily.com/releases/2010/08/100810082640.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins