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Fittest hepatitis C viruses infect transplanted livers

Date:
October 11, 2010
Source:
Rockefeller University Press
Summary:
Not all viruses are created equal. In liver transplant patients with chronic hepatitis C virus (HCV) infection, only viruses that can dodge the immune response invade the new liver, according to a new study.

Not all viruses are created equal. In liver transplant patients with chronic hepatitis C virus (HCV) infection, only viruses that can dodge the immune response invade the new liver, according to a study published on August 16 in The Journal of Experimental Medicine.

Chronic HCV infection is the leading indication for liver transplantation in the US. But installing a new liver does not cure disease; in fact, HCV infects the transplanted liver in nearly all patients.

However, only a subset of the viruses present prior to transplantation show up in the new organ, according to a study lead by Francoise Stoll-Keller and Thomas Baumert at the University of Strasbourg in France. Compared to many of their pre-transplant brethren, the viruses that invaded the new organ infected liver cells more readily and were impervious to the antibodies that normally block infection.

In most patients, the post-transplant viruses had mutations in one region of the surface protein the virus uses to infect cells. Blocking this region may thus provide a new way to prevent reinfection after liver transplant.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Fafi-Kremer, I. Fofana, E. Soulier, P. Carolla, P. Meuleman, G. Leroux-Roels, A. H. Patel, F.-L. Cosset, P. Pessaux, M. Doffoel, P. Wolf, F. Stoll-Keller, T. F. Baumert. Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. Journal of Experimental Medicine, 2010; DOI: 10.1084/jem.20090766

Cite This Page:

Rockefeller University Press. "Fittest hepatitis C viruses infect transplanted livers." ScienceDaily. ScienceDaily, 11 October 2010. <www.sciencedaily.com/releases/2010/08/100816122128.htm>.
Rockefeller University Press. (2010, October 11). Fittest hepatitis C viruses infect transplanted livers. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2010/08/100816122128.htm
Rockefeller University Press. "Fittest hepatitis C viruses infect transplanted livers." ScienceDaily. www.sciencedaily.com/releases/2010/08/100816122128.htm (accessed April 25, 2014).

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