Featured Research

from universities, journals, and other organizations

Sodium MRI gives new insights into detecting osteoarthritis

Date:
August 28, 2010
Source:
New York University
Summary:
Researchers have developed an innovative way to look at the development of osteoarthritis in the knee joint -- one that relies on the examination of sodium ions in cartilage.

Researchers at New York University have developed an innovative way to look at the development of osteoarthritis in the knee joint -- one that relies on the examination of sodium ions in cartilage. Their work, which appears in the Journal of Magnetic Resonance, may provide a non-invasive method to diagnose osteoarthritis in its very early stages.

The concentration of sodium ions, which are distributed in the body, is known to reveal the location of glycosaminogycans (GAGs) in cartilage tissues. GAGs are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Mapping the GAG concentration is necessary for the diagnosis and monitoring of a number of diseases as well as to determine the efficacy of drug therapies. For instance, GAG loss in cartilage typically marks the onset of osteoarthritis and inter-vertebral disc degeneration.

However, the existing techniques for GAG monitoring -- based on traditional magnetic resonance imaging (MRI) -- have limitations: they cannot directly map GAG concentrations or they require the administration of contrast agents to reveal the location of these concentrations.

But since sodium ions are already present in cartilage, researchers have sought to measure these ions using special MRI techniques that are non-invasive.

Such a methodology was previously developed at the University of Pennsylvania and Stanford University. However, these methodologies were not able to isolate ions in different parts of the knee area. Specifically, they could not make clear-cut distinctions between signals of slow motion sodium ions in the cartilage from those of free sodium ions in synovial fluid and joint effusion in the knee joint.

The NYU research team sought to improve on this method by focusing on the differences in the properties of sodium ions in the two environments.

Since sodium is present not only in cartilage, MRI images often cannot tell whether the sodium concentration measured is located in cartilage or elsewhere in the knee joint. To better target where these sodium concentrations reside, the researchers focused on the differences in the magnetic behavior of sodium ions residing in different tissues. By exploiting these characteristic properties of sodium ions in different environments, the research team was able to develop a new method to isolate two pools of sodium ions. As a result, it was able to obtain images in which the sodium signals appear exclusively from regions with cartilage tissue.

This new sodium MRI method not only could provide a non-invasive way to diagnose osteoarthritis in its very early stages, but could also help to calibrate other, less direct measures of cartilage assessments.

The research was conducted by: Alexej Jerschow, an associate professor, and Jae-Seung Lee, a post-doctoral fellow, both in NYU's Department of Chemistry; Ravinder Regatte, an associate professor, and Guillaume Madelin, a post-doctoral fellow, both in the Radiology Department at NYU School of Medicine; and Souheil Inati, a former assistant professor at NYU's Center for Neural Science and currently a staff scientist at the National Institute of Mental Health.


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Guillaume Madelin, Jae-Seung Lee, Souheil Inati, Alexej Jerschow, Ravinder R. Regatte. Sodium Inversion Recovery MRI of the Knee Joint In Vivo at 7T. Journal of Magnetic Resonance, 2010; DOI: 10.1016/j.jmr.2010.08.003

Cite This Page:

New York University. "Sodium MRI gives new insights into detecting osteoarthritis." ScienceDaily. ScienceDaily, 28 August 2010. <www.sciencedaily.com/releases/2010/08/100827112942.htm>.
New York University. (2010, August 28). Sodium MRI gives new insights into detecting osteoarthritis. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/08/100827112942.htm
New York University. "Sodium MRI gives new insights into detecting osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2010/08/100827112942.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins