Featured Research

from universities, journals, and other organizations

Risk factors for cardiovascular events in patients with atherothrombosis

Date:
August 30, 2010
Source:
JAMA and Archives Journals
Summary:
Clinical descriptors can assist clinicians in identifying patients with various stages of atherothrombosis (abnormal fatty deposits in an artery) who are at high-risk of future cardiovascular events, according to a new study.

Clinical descriptors can assist clinicians in identifying patients with various stages of atherothrombosis (abnormal fatty deposits in an artery) who are at high-risk of future cardiovascular events, according to a study that will appear in the September 22 issue of JAMA. The study is being released early online to coincide with its presentation at the European Society of Cardiology meeting in Stockholm.

Related Articles


"Patients with atherothrombosis are at elevated risk of ischemic events [such as heart attack or stroke] but, depending on their specific manifestations of atherothrombosis, may have varying degrees of future risk for ischemic events," the authors write as background in the article. "For clinicians, the ability to identify rapidly the major determinants of risk among patients with atherosclerosis would be useful to triage novel preventive therapies toward those at the higher end of the spectrum."

Deepak L. Bhatt, M.D., M.P.H., of the VA Boston Healthcare System, Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues studied 45,227 patients who were enrolled in the global Reduction of Atherothrombosis for Continued Health (REACH) study. Detailed information was gathered at baseline, with additional annual follow-up at one, two, three and four years. Patients were enrolled between 2003 and 2004 and follow-up continued until 2008. Hypertension and hypercholesterolemia (high cholesterol levels in the blood) were common, present in 81.3 percent and 70.4 percent of patients, respectively. Additionally, polyvascular disease (atherosclerotic disease in multiple arterial territories) was present in 15.9 percent of patients and 48.4 percent had prior ischemic events, with 28.1 percent of those having an ischemic event within the previous year.

During the follow-up period, 5,481 patients experienced cardiovascular events including 2,315 with cardiovascular death, 1,228 with myocardial infarction (heart attack), 1,898 with stroke and 40 with both a myocardial infarction and stroke occurring on the same day. Additionally, among patients with atherothrombosis, those with a prior history of ischemic events at baseline had the highest rate of subsequent ischemic events, while patients with stable coronary, cerebrovascular or peripheral artery disease had a lower risk. Patients without established atherothrombosis but with risk factors only had the lowest risk of subsequent ischemic events.

"Among all categories of patients, diabetes substantially increased the risk of future ischemic events," the authors write. "In those with established atherothrombosis, polyvascular disease was a particularly strong independent risk factor, even stronger than diabetes." Additionally, the authors conclude that, "this analysis of a contemporary, international cohort of patients at various stages of atherothrombosis shows that there is a whole spectrum of ischemic risk in patients with risk factors or with established cardiovascular disease and that easily ascertainable clinical characteristics are the prominent factors associated with a high risk of future ischemic events."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Deepak L. Bhatt et al. Comparative Determinants of 4-Year Cardiovascular Event Rates in Stable Outpatients at Risk of or With Atherothrombosis. JAMA, 2010; DOI: 10.1001/jama.2010.1322

Cite This Page:

JAMA and Archives Journals. "Risk factors for cardiovascular events in patients with atherothrombosis." ScienceDaily. ScienceDaily, 30 August 2010. <www.sciencedaily.com/releases/2010/08/100830082906.htm>.
JAMA and Archives Journals. (2010, August 30). Risk factors for cardiovascular events in patients with atherothrombosis. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2010/08/100830082906.htm
JAMA and Archives Journals. "Risk factors for cardiovascular events in patients with atherothrombosis." ScienceDaily. www.sciencedaily.com/releases/2010/08/100830082906.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins