Featured Research

from universities, journals, and other organizations

Stress resilience returns with feeling for rhythm

Date:
September 23, 2010
Source:
NWO (Netherlands Organization for Scientific Research)
Summary:
If your body releases cortisol with fixed regularity then you can cope with stress better, according to new Dutch research into the rhythm of corticosterone production in rats. This rat hormone is comparable to the human stress hormone cortisol. Rats deal considerably less well with stress if the pattern of corticosterone release changes. An irregular release pattern is a characteristic of chronic stress and stress-related diseases. It might therefore be possible to treat these by restoring the rhythm.

If your body releases cortisol with fixed regularity then you can cope with stress better, says NWO-funded researcher Angela Sarabdjitsingh. She investigated the rhythm of corticosterone production in rats. This rat hormone is comparable to the human stress hormone cortisol. Rats deal considerably less well with stress if the pattern of corticosterone release changes. An irregular release pattern is a characteristic of chronic stress and stress-related diseases. It might therefore be possible to treat these by restoring the rhythm.

The hormone cortisol has to activate other proteins in the body and brain for a satisfactory response to stress. Yet Sarabdjitsingh discovered that important genes are activated less as soon as the rat's body is exposed to flattened corticosterone patterns. In a flattened pattern individual pulses are no longer recognisable as there are no more hourly peaks or troughs. That is interesting because conditions such as depression are characterised by a flattened rhythm in the cortisol release. Therefore it might be possible to treat such conditions by using medicines to adjust the rhythm.

Every hour the adrenal glands release the stress hormone cortisol (in rats corticosterone). However, disease or ageing can cause considerable disruption to this hourly rhythm with the result that the body responds less well to stress and pressure. Sarabdjitsingh investigated how the rhythm influences the stress response and the resilience of the hormonal and behavioural stress reaction. She also investigated if any changes in the pattern took place in tissues influenced by the stress hormone.

Crucial protein

Besides discovering that the rhythm of corticosterone release is crucial for a good hormonal and behavioural stress response, Sarabdjitsingh found out which protein predominantly suffers under a disrupted rhythm: the glucocorticoid receptor. This protein could therefore be an ideal target for the treatment of stress and stress-related diseases.

Mosaic

Angela Sarabdjitsingh obtained these results by being the first to combine a number of advanced techniques. These methods are now being used by other research groups as well to explore the subject further. Sarabdjitsingh carried out her unique research with a grant from the NWO Mosaic programme. Mosaic is a grant programme that funds the PhD research of students from ethnic minorities. Ethnic minorities are underrepresented within science and NWO, as a strong proponent of diversity, regrets the small number of role models. With Mosaic, NWO wants to prevent scientific talent from being unnecessarily lost.


Story Source:

The above story is based on materials provided by NWO (Netherlands Organization for Scientific Research). Note: Materials may be edited for content and length.


Cite This Page:

NWO (Netherlands Organization for Scientific Research). "Stress resilience returns with feeling for rhythm." ScienceDaily. ScienceDaily, 23 September 2010. <www.sciencedaily.com/releases/2010/08/100831073617.htm>.
NWO (Netherlands Organization for Scientific Research). (2010, September 23). Stress resilience returns with feeling for rhythm. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/08/100831073617.htm
NWO (Netherlands Organization for Scientific Research). "Stress resilience returns with feeling for rhythm." ScienceDaily. www.sciencedaily.com/releases/2010/08/100831073617.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins