Featured Research

from universities, journals, and other organizations

Stress resilience returns with feeling for rhythm

Date:
September 23, 2010
Source:
NWO (Netherlands Organization for Scientific Research)
Summary:
If your body releases cortisol with fixed regularity then you can cope with stress better, according to new Dutch research into the rhythm of corticosterone production in rats. This rat hormone is comparable to the human stress hormone cortisol. Rats deal considerably less well with stress if the pattern of corticosterone release changes. An irregular release pattern is a characteristic of chronic stress and stress-related diseases. It might therefore be possible to treat these by restoring the rhythm.

If your body releases cortisol with fixed regularity then you can cope with stress better, says NWO-funded researcher Angela Sarabdjitsingh. She investigated the rhythm of corticosterone production in rats. This rat hormone is comparable to the human stress hormone cortisol. Rats deal considerably less well with stress if the pattern of corticosterone release changes. An irregular release pattern is a characteristic of chronic stress and stress-related diseases. It might therefore be possible to treat these by restoring the rhythm.

The hormone cortisol has to activate other proteins in the body and brain for a satisfactory response to stress. Yet Sarabdjitsingh discovered that important genes are activated less as soon as the rat's body is exposed to flattened corticosterone patterns. In a flattened pattern individual pulses are no longer recognisable as there are no more hourly peaks or troughs. That is interesting because conditions such as depression are characterised by a flattened rhythm in the cortisol release. Therefore it might be possible to treat such conditions by using medicines to adjust the rhythm.

Every hour the adrenal glands release the stress hormone cortisol (in rats corticosterone). However, disease or ageing can cause considerable disruption to this hourly rhythm with the result that the body responds less well to stress and pressure. Sarabdjitsingh investigated how the rhythm influences the stress response and the resilience of the hormonal and behavioural stress reaction. She also investigated if any changes in the pattern took place in tissues influenced by the stress hormone.

Crucial protein

Besides discovering that the rhythm of corticosterone release is crucial for a good hormonal and behavioural stress response, Sarabdjitsingh found out which protein predominantly suffers under a disrupted rhythm: the glucocorticoid receptor. This protein could therefore be an ideal target for the treatment of stress and stress-related diseases.

Mosaic

Angela Sarabdjitsingh obtained these results by being the first to combine a number of advanced techniques. These methods are now being used by other research groups as well to explore the subject further. Sarabdjitsingh carried out her unique research with a grant from the NWO Mosaic programme. Mosaic is a grant programme that funds the PhD research of students from ethnic minorities. Ethnic minorities are underrepresented within science and NWO, as a strong proponent of diversity, regrets the small number of role models. With Mosaic, NWO wants to prevent scientific talent from being unnecessarily lost.


Story Source:

The above story is based on materials provided by NWO (Netherlands Organization for Scientific Research). Note: Materials may be edited for content and length.


Cite This Page:

NWO (Netherlands Organization for Scientific Research). "Stress resilience returns with feeling for rhythm." ScienceDaily. ScienceDaily, 23 September 2010. <www.sciencedaily.com/releases/2010/08/100831073617.htm>.
NWO (Netherlands Organization for Scientific Research). (2010, September 23). Stress resilience returns with feeling for rhythm. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2010/08/100831073617.htm
NWO (Netherlands Organization for Scientific Research). "Stress resilience returns with feeling for rhythm." ScienceDaily. www.sciencedaily.com/releases/2010/08/100831073617.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins