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Why the craving for cocaine won’t go away

Date:
September 16, 2010
Source:
Expertanswer (Expertsvar in Swedish)
Summary:
People who have used cocaine run a great risk of becoming addicted, even after long drug-free periods. Now researchers in Sweden and their colleagues can point to a specific molecule in the brain as a possible target for treatment to prevent relapses.

People who have used cocaine run a great risk of becoming addicted, even after long drug-free periods. Now researchers at Linkφping University and their colleagues can point to a specific molecule in the brain as a possible target for treatment to prevent relapses.

Drugs are addictive because they "hijack" the brain's reward system, which is actually intended to make it pleasurable to eat and have sex, behaviors that are necessary for survival and reproduction.

This "hijacking" is extremely long-lived and often leads to relapses into abuse, especially when the individual is exposed to stimuli in the surroundings that are associated with the drug. In an article in the Journal of Neuroscience the research team can now show that a receptor for the signal substance glutamate (mGluR5), in a part of the brain called the striatum, plays a major role in relapses.

The study, led by David Engblom, associate professor of neurobiology at Linkφping University in Sweden, looks at what happens in individuals who lack the glutamate receptor. The experiments were performed on mice that were taught to ingest cocaine.

"Our findings show that the mice who lacked the receptor were less prone to relapse. This is due the fact that their reaction to reward had not been etched into their memories in the same ways as in normal mice. The receptor seems to be a prerequisite for objects or environments that were previously associated with taking drugs, or something else rewarding, to create a craving," says David Engblom.

He hopes that these findings and other studies of mechanisms underlying drug addiction can lead to forms of treatment based on what goes wrong in the brain of an addict.


Story Source:

The above story is based on materials provided by Expertanswer (Expertsvar in Swedish). Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Novak, B. Halbout, E. C. O'Connor, J. Rodriguez Parkitna, T. Su, M. Chai, H. S. Crombag, A. Bilbao, R. Spanagel, D. N. Stephens, G. Schutz, D. Engblom. Incentive Learning Underlying Cocaine-Seeking Requires mGluR5 Receptors Located on Dopamine D1 Receptor-Expressing Neurons. Journal of Neuroscience, 2010; 30 (36): 11973 DOI: 10.1523/JNEUROSCI.2550-10.2010

Cite This Page:

Expertanswer (Expertsvar in Swedish). "Why the craving for cocaine won’t go away." ScienceDaily. ScienceDaily, 16 September 2010. <www.sciencedaily.com/releases/2010/09/100916073416.htm>.
Expertanswer (Expertsvar in Swedish). (2010, September 16). Why the craving for cocaine won’t go away. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2010/09/100916073416.htm
Expertanswer (Expertsvar in Swedish). "Why the craving for cocaine won’t go away." ScienceDaily. www.sciencedaily.com/releases/2010/09/100916073416.htm (accessed August 28, 2014).

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