Featured Research

from universities, journals, and other organizations

Increased brain protein levels linked to Alzheimer's disease

Date:
September 16, 2010
Source:
University of California - San Diego
Summary:
Elevated levels of a growth protein in the brains of Alzheimer's disease patients is linked to impaired neurogenesis, the process by which new neurons are generated, say researchers.

Elevated levels of a growth protein in the brains of Alzheimer's disease (AD) patients is linked to impaired neurogenesis, the process by which new neurons are generated, say researchers at the University of California, San Diego in The Journal of Neuroscience.

Related Articles


Eliezer Masliah, MD, professor of neurosciences and pathology in the UC San Diego School of Medicine and colleagues report that increased levels of BMP6 -- part of a family of bone morphogenetic proteins involved in cell signaling and growth -- were found in the brains of Alzheimer's patients and in mouse models of the disease.

BMP6 is primarily known to be involved in bone growth and the proliferation of non-neuronal glial cells in developing embryos. Its purpose in adult brains is less clear. "As a growth factor, it might initially be expressed for protective effect, a response to accumulating amyloid plaque proteins in Alzheimer's patients," said first author Leslie Crews, a post-doctoral researcher in Masliah's lab.

But too much BMP6 appears to be increasingly detrimental. Researchers found that levels of BMP6 grew in step with the progression of Alzheimer's disease. "In early stages of AD, there was less protein than there was in later, more advanced stages," said Crews.

Higher-than-normal levels of BMP6 were found in the dentate gyrus of Alzheimer's patients and around characteristic amyloid plaques in the hippocampus. Both regions of the brain are critical to memory formation and storage.

In cell cultures, the scientists found that BMP6 reduced the proliferation of cells, a discovery that suggests the protein could be a potential therapeutic target. "The next step is to see what happens when we normalize expression of BMP6," said Masliah. "If we can do that, it may possible to impact this part of AD's pathogenesis."

The protein provides an easier target than some molecules, said Crews, because it is secreted and circulates around cells in the brain. "We don't have to figure out how to get it into the brain and into cells," she said.

Co-authors of the study are Anthony Adame, Christina Patrick, Alexandra DeLaney, Emiley Pham and Edward Rockenstein of the Department of Neurosciences at UC San Diego and Lawrence Hansen of the Departments of Neurosciences and Pathology at UCSD.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leslie Crews, Anthony Adame, Christina Patrick, Alexandra DeLaney, Emiley Pham, Edward Rockenstein, Lawrence Hansen, and Eliezer Masliah. Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis. Journal of Neuroscience, 2010; 30: 12252-12262 DOI: 10.1523/JNEUROSCI.1305-10.2010

Cite This Page:

University of California - San Diego. "Increased brain protein levels linked to Alzheimer's disease." ScienceDaily. ScienceDaily, 16 September 2010. <www.sciencedaily.com/releases/2010/09/100916091753.htm>.
University of California - San Diego. (2010, September 16). Increased brain protein levels linked to Alzheimer's disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/09/100916091753.htm
University of California - San Diego. "Increased brain protein levels linked to Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2010/09/100916091753.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) — Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins