Featured Research

from universities, journals, and other organizations

Increased brain protein levels linked to Alzheimer's disease

Date:
September 16, 2010
Source:
University of California - San Diego
Summary:
Elevated levels of a growth protein in the brains of Alzheimer's disease patients is linked to impaired neurogenesis, the process by which new neurons are generated, say researchers.

Elevated levels of a growth protein in the brains of Alzheimer's disease (AD) patients is linked to impaired neurogenesis, the process by which new neurons are generated, say researchers at the University of California, San Diego in The Journal of Neuroscience.

Eliezer Masliah, MD, professor of neurosciences and pathology in the UC San Diego School of Medicine and colleagues report that increased levels of BMP6 -- part of a family of bone morphogenetic proteins involved in cell signaling and growth -- were found in the brains of Alzheimer's patients and in mouse models of the disease.

BMP6 is primarily known to be involved in bone growth and the proliferation of non-neuronal glial cells in developing embryos. Its purpose in adult brains is less clear. "As a growth factor, it might initially be expressed for protective effect, a response to accumulating amyloid plaque proteins in Alzheimer's patients," said first author Leslie Crews, a post-doctoral researcher in Masliah's lab.

But too much BMP6 appears to be increasingly detrimental. Researchers found that levels of BMP6 grew in step with the progression of Alzheimer's disease. "In early stages of AD, there was less protein than there was in later, more advanced stages," said Crews.

Higher-than-normal levels of BMP6 were found in the dentate gyrus of Alzheimer's patients and around characteristic amyloid plaques in the hippocampus. Both regions of the brain are critical to memory formation and storage.

In cell cultures, the scientists found that BMP6 reduced the proliferation of cells, a discovery that suggests the protein could be a potential therapeutic target. "The next step is to see what happens when we normalize expression of BMP6," said Masliah. "If we can do that, it may possible to impact this part of AD's pathogenesis."

The protein provides an easier target than some molecules, said Crews, because it is secreted and circulates around cells in the brain. "We don't have to figure out how to get it into the brain and into cells," she said.

Co-authors of the study are Anthony Adame, Christina Patrick, Alexandra DeLaney, Emiley Pham and Edward Rockenstein of the Department of Neurosciences at UC San Diego and Lawrence Hansen of the Departments of Neurosciences and Pathology at UCSD.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leslie Crews, Anthony Adame, Christina Patrick, Alexandra DeLaney, Emiley Pham, Edward Rockenstein, Lawrence Hansen, and Eliezer Masliah. Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis. Journal of Neuroscience, 2010; 30: 12252-12262 DOI: 10.1523/JNEUROSCI.1305-10.2010

Cite This Page:

University of California - San Diego. "Increased brain protein levels linked to Alzheimer's disease." ScienceDaily. ScienceDaily, 16 September 2010. <www.sciencedaily.com/releases/2010/09/100916091753.htm>.
University of California - San Diego. (2010, September 16). Increased brain protein levels linked to Alzheimer's disease. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/09/100916091753.htm
University of California - San Diego. "Increased brain protein levels linked to Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2010/09/100916091753.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins