Featured Research

from universities, journals, and other organizations

New method of chemical analysis: Step towards personalized medicine

Date:
September 22, 2010
Source:
Institute of Physical Chemistry of the Polish Academy of Sciences
Summary:
In the future, even before the start of the treatment, physicians will be able to establish how patient's blood binds a given medicine and what doze should be applied in order to obtain the concentration in the body that would be optimal for the treatment.

New method of analysis of chemical reaction equilibrium consists in the examination of the flow of a liquid in a long and thin tube -- a capillary. In the photo there is a PhD student Paulina Dobosz from the Institute of Physical Chemistry of the PAS standing next to a liquid chromatograph, with a capillary in her hand.
Credit: IPC PAS, Grzegorz Krzyżewski

In the future, even before the start of a particular treatment, physicians will be able to establish how patient's blood binds a given medicine and what doze should be applied in order to obtain the concentration in the body that would be optimal for the treatment. A new simple method of analysis of chemical reactions proceeding in solutions has been developed in the Institute of Physical Chemistry of the Polish Academy of Sciences.

Related Articles


Information on how strongly two dissolved substances react with each other is very important in many fields, in particular in chemistry, molecular biology, pharmacy and medicine. The new analytical technique, developed at the Institute of Physical Chemistry of the PAS (IPC PAS), allows the inexpensive and reliable determination of stability of complexes created as a result of reactions between chemical compounds in solutions. What is interesting, the measurement involves very simple physical phenomena and comes down to the examination of the flow of a solution of two compounds in a long and thin tube -- a capillary.

Every angler knows that rivers flow fastest in the middle part of the stream, and near the banks the current is always slower. A liquid flowing through a capillary behaves in a similar way. If the flow is nonturbulent (laminar), the layers of the fluid that are closest to the centre of the capillary flow faster than the layers near the walls. "This is the fact that we use in our method, but the key are phenomena connected with diffusion," says PhD Anna Bielejewska from the IPC PAS. In reality, particles of a liquid may move (diffuse) from a layer flowing with a certain speed to another layer flowing with a different speed. If we insert a substance into a capillary filled with the solution of another substance, the diffusion rate will depend on how strongly the chemical compounds of both solutions react with each other. If particles move quickly between the layers, a detector will register a high and narrow peak. The slower the particles diffuse between layers, the wider the peak. "If we measure the width of the peaks before and after the introduction of a complexing agent into the capillary, we can determine the diffusion coefficients of a free substance and a complexed substance, and on this basis calculate a binding constant. It provides information whether given chemical substances bind with each other or not, and if yes, how permanent the bond is," explains PhD Bielejewska.

The device developed in the Institute of Physical Chemistry comprises a pump which guarantees the stable flow of the liquid at 0.05 millilitre per minute, an autosampler inserting a sample, a detector of visible and ultraviolet radiation and a 0.25 mm diameter capillary, 25 m long, wound around a small cylinder. The obtained results of measurement agreed perfectly with the data collected by classical chromatographic methods and figures cited in international scientific publications. In one of the numerous tests conducted, the capillary was filled with the solution of diluted blood plasma, which contains protein (albumin), after which warfarin, an organic chemical compound used as an anticoagulant, was injected. In this case the results of the experiment were also correct.

The new analytical technique, for which a patent application has already been submitted, may be applied not only in chemistry but also in medicine for the selection of dozes of medicines whose concentration in blood should be strictly determined. "At present a physician first prescribes a medicine to a patient, then takes a blood test and, if something is wrong, changes the doze, checks again and this procedure is repeated until it succeeds. Thanks to our method it will be possible to take several millilitres of blood once before the treatment and determine how strongly the blood binds a given medicine," says Bielejewska. A single analysis using this method lasts approximately half an hour. After this time appropriate software would provide the physician with a result in the form of a doze of medicine adapted to specific features of a given patient's organism.

"We have developed a new, efficient method for the analysis of chemical reaction equilibrium in solutions, for which cheap and simple measurement equipment is required. It is up to the industry whether the method becomes widespread," comments Prof. Robert Hołyst from the Institute of Physical Chemistry of the PAS.


Story Source:

The above story is based on materials provided by Institute of Physical Chemistry of the Polish Academy of Sciences. Note: Materials may be edited for content and length.


Cite This Page:

Institute of Physical Chemistry of the Polish Academy of Sciences. "New method of chemical analysis: Step towards personalized medicine." ScienceDaily. ScienceDaily, 22 September 2010. <www.sciencedaily.com/releases/2010/09/100922082341.htm>.
Institute of Physical Chemistry of the Polish Academy of Sciences. (2010, September 22). New method of chemical analysis: Step towards personalized medicine. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2010/09/100922082341.htm
Institute of Physical Chemistry of the Polish Academy of Sciences. "New method of chemical analysis: Step towards personalized medicine." ScienceDaily. www.sciencedaily.com/releases/2010/09/100922082341.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

AFP (Nov. 21, 2014) Toyota presented its hydrogen fuel-cell compact car called "Mirai" to US consumers at the Los Angeles auto show. The car should go on sale in 2015 for around $60.000. It combines stored hydrogen with oxygen to generate its own power. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Google Announces Improvements To Balloon-Borne Wi-Fi Project

Google Announces Improvements To Balloon-Borne Wi-Fi Project

Newsy (Nov. 21, 2014) In a blog post, Google said its balloons have traveled 3 million kilometers since the start of Project Loon. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
British 'Bio-Bus' Is Powered By Human Waste

British 'Bio-Bus' Is Powered By Human Waste

Buzz60 (Nov. 21, 2014) British company GENeco debuted what its calling the Bio-Bus, a bus fueled entirely by biomethane gas produced from food scraps and sewage. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins