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Ingredient in soap points toward new drugs for infection that affects two billion

Date:
September 23, 2010
Source:
American Chemical Society
Summary:
The antibacterial ingredient in some soaps, toothpastes, odor-fighting socks, and even computer keyboards is pointing scientists toward a long-sought new treatment for a parasitic disease that affects almost two billion people.

The antibacterial ingredient in some soaps, toothpastes, odor-fighting socks, and even computer keyboards is pointing scientists toward a long-sought new treatment for a parasitic disease that affects almost two billion people. Their report on how triclosan became the guiding light for future development of drugs for toxoplasmosis appears in ACS' monthly Journal of Medicinal Chemistry.

In the study, Rima McLeod and colleagues point out that toxoplasmosis is one of the world's most common parasitic infections, affecting about one-third of the world population, including 80 percent of the population of Brazil. People can catch the infection, spread by the parasite Toxoplasma gondii (T. gondii), from contact with feces from infected cats, eating raw or undercooked meat, and in other ways. Many have no symptoms because their immune systems keep the infection under control and the parasite remains inactive. But it can cause eye damage and other problems, even becoming life threatening in individuals with immune systems weakened by certain medications and diseases like HIV infection, which allow the parasite to become active again, and in some persons without immune compromise. Most current treatments have some potentially harmful side effects and none of them attack the parasite in its inactive stage.

The scientists knew from past research that triclosan has a powerful effect in blocking the action of a key enzyme that T. gondii uses to live. Triclosan, however, cannot be used as a medication because it does not dissolve in the blood. The scientists describe using triclosan's molecular structure as the model for developing other potential medications, including some that show promise as more effective treatments for the disease.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Suresh K. Tipparaju, Stephen P. Muench, Ernest J. Mui, Sergey N. Ruzheinikov, Jeffrey Z. Lu, Samuel L. Hutson, Michael J. Kirisits, Sean T. Prigge, Craig W. Roberts, Fiona L. Henriquez, Alan P. Kozikowski, David W. Rice, Rima L. McLeod. Identification and Development of Novel Inhibitors ofToxoplasma gondiiEnoyl Reductase. Journal of Medicinal Chemistry, 2010; 53 (17): 6287 DOI: 10.1021/jm9017724

Cite This Page:

American Chemical Society. "Ingredient in soap points toward new drugs for infection that affects two billion." ScienceDaily. ScienceDaily, 23 September 2010. <www.sciencedaily.com/releases/2010/09/100922121953.htm>.
American Chemical Society. (2010, September 23). Ingredient in soap points toward new drugs for infection that affects two billion. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2010/09/100922121953.htm
American Chemical Society. "Ingredient in soap points toward new drugs for infection that affects two billion." ScienceDaily. www.sciencedaily.com/releases/2010/09/100922121953.htm (accessed July 25, 2014).

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