Featured Research

from universities, journals, and other organizations

Intriguing viral link to intestinal cancer in mice

Date:
October 11, 2010
Source:
Journal of Clinical Investigation
Summary:
More than 50 percent of adults in the United States test positive for human cytomegalovirus (HCMV) infection. For most people, infection produces no symptoms and results in the virus persisting in the body for a long time. New research in mice now suggests that it is possible that HCMV infection could help promote intestinal cancer in humans, although more human studies are needed if such an association is to be confirmed.

More than 50% of adults in the United States test positive for human cytomegalovirus (HCMV) infection. For most people, infection produces no symptoms and results in the virus persisting in the body for a long time. HCMV infects many cell types in the body including the cells that line the intestines (IECs). New research, led by Sergio Lira, at Mount Sinai School of Medicine, New York, shows that mice engineered to express the HCMV protein US28 in IECs develop intestinal tumors as they age.

These mice also develop more tumors than normal mice in a model of inflammation-induced intestinal tumors.

The authors therefore suggest that it is possible that HCMV infection could help promote intestinal cancer in humans, although they caution that much more work is needed if such an association is to be confirmed.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gerold Bongers et al. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. Journal of Clinical Investigation, 2010 DOI: 10.1172/JCI42563

Cite This Page:

Journal of Clinical Investigation. "Intriguing viral link to intestinal cancer in mice." ScienceDaily. ScienceDaily, 11 October 2010. <www.sciencedaily.com/releases/2010/10/101011125833.htm>.
Journal of Clinical Investigation. (2010, October 11). Intriguing viral link to intestinal cancer in mice. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/10/101011125833.htm
Journal of Clinical Investigation. "Intriguing viral link to intestinal cancer in mice." ScienceDaily. www.sciencedaily.com/releases/2010/10/101011125833.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins