Featured Research

from universities, journals, and other organizations

Gene linked to drug resistance in malaria pinpointed

Date:
October 12, 2010
Source:
University of Edinburgh
Summary:
Scientists have shed light on how malaria is able to resist treatment with a leading drug. Researchers have identified a gene that enables the parasite that causes the infection to resist treatment with the plant-based remedy artemisinin.

Scientists have shed light on how malaria is able to resist treatment with a leading drug.

Researchers have identified a gene that enables the parasite that causes the infection to resist treatment with the plant-based remedy artemisinin.

In many countries where the parasite has developed resistance to previously effective common treatments such as chloroquine, artemisinin remains the only effective treatment against the infection. However, malarial resistance to artemisinin appears to be developing, potentially creating problems in controlling malaria.

Identification of this gene paves the way for further studies that could eventually help control the development of resistance to artemisinin and lead to more effective drugs for human malaria.

The study, by scientists from the University of Edinburgh and the Universidade Nova de Lisboa, used emerging technology to scan the genetic fingerprint of drug resistant parasites that infect rodents. This technology allows rapid identification of genes that enable the parasite to withstand existing drug treatments.

There are estimated to be between 300 and 500 million cases of malaria each year, occurring in over 90 different countries, according to the World Health Organisation.

Dr Paul Hunt, from the University of Edinburgh's School of Biological Sciences, said: "This knowledge from rodent malaria parasites opens up new directions that will allow this gene to be investigated in human malaria. This may help track the evolution of drug resistance and may eventually enable the design of alternative, effective drugs."

The study, published in BMC Genomics, was funded by the Medical Research Council.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Paul Hunt, Axel Martinelli, Katarzyna Modrzynska, Sofia Borges, Alison Creasey, Louise Rodrigues, Dario Beraldi, Laurence Loewe, Richard Fawcett, Sujai Kumar, Marian Thomson, Urmi Trivedi, Thomas D Otto, Arnab Pain, Mark Blaxter, Pedro Cravo. Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites. BMC Genomics, 2010; 11 (1): 499 DOI: 10.1186/1471-2164-11-499

Cite This Page:

University of Edinburgh. "Gene linked to drug resistance in malaria pinpointed." ScienceDaily. ScienceDaily, 12 October 2010. <www.sciencedaily.com/releases/2010/10/101012101629.htm>.
University of Edinburgh. (2010, October 12). Gene linked to drug resistance in malaria pinpointed. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/10/101012101629.htm
University of Edinburgh. "Gene linked to drug resistance in malaria pinpointed." ScienceDaily. www.sciencedaily.com/releases/2010/10/101012101629.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins