Featured Research

from universities, journals, and other organizations

New evidence of common gastric infection as invasive pathogen may explain antibiotic resistance

Date:
October 16, 2010
Source:
American Society for Microbiology
Summary:
Helicobacter pylori, the bacterium largely associated with gastritis and peptic ulcers in humans, may invade and replicate in gastric epithelial cells say researchers from China. This discovery disputes prior views of H. pylori as a noninvasive pathogen and could offer significant insight into its ability to resist antibacterial therapy and its biological life cycle as a whole.

Helicobacter pylori, the bacterium largely associated with gastritis and peptic ulcers in humans, may invade and replicate in gastric epithelial cells say researchers from China. This discovery disputes prior views of H. pylori as a noninvasive pathogen and could offer significant insight into its ability to resist antibacterial therapy and its biological life cycle as a whole.

The details are reported in the October 2010 issue of the journal Infection and Immunity.

H. pylori infects more than 50% of the human population in developing countries, however, symptoms such as chronic active gastritis and peptic ulcers only manifest in 10 to 20% of those infected. Until now, H. pylori has been generally considered noninvasive, but current research indicates that it may replicate on the cell membrane ultimately forming a microcolony.

"This suggests that H. pylori can be considered a facultative intracellular organism," say the researchers.

In the study testing was conducted to determine if H. pylori could invade and multiply in gastric epithelial cells. Results showed a 5-fold increase in the number of bacteria cultured from infected cells 12 hours following infection when compared with the number of invading cells observed after 2 and a half hours. Additionally, the researchers note that only cell-penetrating antibiotics may effectively kill intracellular replicating H. pylori bacteria.

"The multiplication of H. pylori within cells provides a niche for its resistance to antibacterial therapy and has a significant impact on its biological life cycle," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y.-T. Chu, Y.-H. Wang, J.-J. Wu, H.-Y. Lei. Invasion and Multiplication of Helicobacter pylori in Gastric Epithelial Cells and Implications for Antibiotic Resistance. Infection and Immunity, 2010; 78 (10): 4157 DOI: 10.1128/IAI.00524-10

Cite This Page:

American Society for Microbiology. "New evidence of common gastric infection as invasive pathogen may explain antibiotic resistance." ScienceDaily. ScienceDaily, 16 October 2010. <www.sciencedaily.com/releases/2010/10/101016080016.htm>.
American Society for Microbiology. (2010, October 16). New evidence of common gastric infection as invasive pathogen may explain antibiotic resistance. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/10/101016080016.htm
American Society for Microbiology. "New evidence of common gastric infection as invasive pathogen may explain antibiotic resistance." ScienceDaily. www.sciencedaily.com/releases/2010/10/101016080016.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins