Featured Research

from universities, journals, and other organizations

Seeking Genetics-Specific Treatments for Age-Related Macular Degeneration

Date:
October 17, 2010
Source:
American Academy of Ophthalmology
Summary:
In the past decade ophthalmologists gained a powerful tool to control vision-damaging "wet" age-related macular degeneration (wet AMD): anti-vascular endothelial growth factor (anti-VEGF) medications. Anti-VEGF drugs halt or even reverse damage in many wet AMD patients, but some do not respond as well to treatment and so suffer severe vision loss.

In the past decade ophthalmologists gained a powerful tool to control vision-damaging "wet" age-related macular degeneration (wet AMD): anti-vascular endothelial growth factor (anti-VEGF) medications. Anti-VEGF drugs halt or even reverse damage in many wet AMD patients, but some do not respond as well to treatment and so suffer severe vision loss.

The new field of pharmacogenetics seeks to enable doctors to individualize treatment based on the patient's genetic profile for a disease. In a collaborative effort, the Hussman Institute for Human Genomics and Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine studied whether specific genetic AMD risk factors and/or smoking influenced patients' responses to anti-VEGF treatment.

The researchers reviewed medical records of 36 people with wet AMD who participated in the Unifying Genetic Epidemiology of Macular Degeneration Study. In terms of anti-VEGF treatment, there were 12 responders whose vision improved, 18 maintainers, and 6 poor responders whose vision declined. All patients had been treated with bevacizumab (Avastin) and/or ranibizumab (Lucentis) for at least one year. None of the patients had vision loss due to cataract, geographic atrophy (advanced "dry" AMD), laser scar or retinal pigment epithelial tear. DNA analysis was done for two AMD-genetic risk factors: complement factor H (CFH) and age-related maculopathy susceptibility-2 (ARMS2) genes. Twenty-four patients had been smokers and three were current smokers. The average age was 80 years.

"Neither high risk genetic factors nor smoking history was significantly associated with patients' response to anti-VEGF therapy in our study," said Jaclyn L Kovach, MD. "However, more responders than poor responders carried at least one risk allele for ARMS2, CFH, or for both genes. Repeating this study in a larger population could bring us closer to a gene-guided therapy for wet AMD."

AMD is categorized as either "dry" or "wet." In the advanced "wet" form, abnormal new blood vessels develop under the retina that bleed or leak fluid and form scars. Advanced AMD destroys the detailed, central vision we need to recognize faces, read, drive, and enjoy daily life.This research was presented at the 2010 American Academy of Ophthalmology -- Middle East-Africa Council of Ophthalmology Joint Meeting. The AAO-MEACO meeting is in session Oct. 16-19 in Chicago.


Story Source:

The above story is based on materials provided by American Academy of Ophthalmology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Ophthalmology. "Seeking Genetics-Specific Treatments for Age-Related Macular Degeneration." ScienceDaily. ScienceDaily, 17 October 2010. <www.sciencedaily.com/releases/2010/10/101017133633.htm>.
American Academy of Ophthalmology. (2010, October 17). Seeking Genetics-Specific Treatments for Age-Related Macular Degeneration. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/10/101017133633.htm
American Academy of Ophthalmology. "Seeking Genetics-Specific Treatments for Age-Related Macular Degeneration." ScienceDaily. www.sciencedaily.com/releases/2010/10/101017133633.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins