Featured Research

from universities, journals, and other organizations

New strategy to kill bugs -- even those in hiding

Date:
October 29, 2010
Source:
University of Hertfordshire
Summary:
New strategies to apply antibiotics more effectively to hibernating bugs have been developed by researchers in the UK.

New strategies to apply antibiotics more effectively to hibernating bugs have been developed by researchers at the University of Hertfordshire.

In a paper, which appeared this month in the Institute of Electrical and Electronics Engineers (IEEE) Transactions on Evolutionary Computing, Dr Ole Steuernagel and Dr Daniel Polani from the University's Science and Technology Research Institute describe how to apply antibiotics to wipe out bacteria that form active as well as inactive subpopulations.

"One of the difficulties of applying antibiotic strategies against bugs is that some of the microbes tend to go into hibernation," said Dr Steuernagel. "Although the medication can wipe out the active populations, it often misses the hibernating ones because they are metabolically inactive. It may not be enough just to kill off the active bacteria, the hibernating rest will 'wake up' and reestablish themselves."

Through use of an optimization approach called 'multiobjective optimization' that is tailored to such multifaceted scenarios, the researchers found that the best solution is to kill the microbes early and late during the therapy period, but not during the intermediate period.

"This is the first time that this approach has been used in a bug eradication scenario and our solutions should be more efficient than existing approaches to kill hibernating bugs," said Dr Steuernagel. "Current practice does not take account of persistence due to hibernation although this may well be a problem. After all, microbes which are known to hibernate include Escherichia coli, multiply resistant Staphyloccus aureus (MRSA -- "superbug"), Mycobacterium tuberculosis, Pseudomonas aeruginosa."


Story Source:

The above story is based on materials provided by University of Hertfordshire. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ole Steuernagel, Daniel Polani. Multiobjective Optimization Applied to the Eradication of Persistent Pathogens. IEEE Transactions on Evolutionary Computation, 2010; 14 (5): 759 DOI: 10.1109/TEVC.2010.2040181

Cite This Page:

University of Hertfordshire. "New strategy to kill bugs -- even those in hiding." ScienceDaily. ScienceDaily, 29 October 2010. <www.sciencedaily.com/releases/2010/10/101026090832.htm>.
University of Hertfordshire. (2010, October 29). New strategy to kill bugs -- even those in hiding. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2010/10/101026090832.htm
University of Hertfordshire. "New strategy to kill bugs -- even those in hiding." ScienceDaily. www.sciencedaily.com/releases/2010/10/101026090832.htm (accessed August 28, 2014).

Share This




More Plants & Animals News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Super Healthful Fruits and Vegetables: Which Are Best?

Super Healthful Fruits and Vegetables: Which Are Best?

Ivanhoe (Aug. 27, 2014) We all know that it is important to eat our fruits and vegetables but do you know which ones are the best for you? Video provided by Ivanhoe
Powered by NewsLook.com
Bad Memories Turn Good In Weird Mouse Brain Study

Bad Memories Turn Good In Weird Mouse Brain Study

Newsy (Aug. 27, 2014) MIT researchers were able to change whether bad memories in mice made them anxious by flicking an emotional switch in the brain. Video provided by Newsy
Powered by NewsLook.com
Do Couples Who Smoke Weed Together Stay Together?

Do Couples Who Smoke Weed Together Stay Together?

Newsy (Aug. 27, 2014) A study out of University at Buffalo claims couples who smoke marijuana are less likely to experience intimate partner violence. Video provided by Newsy
Powered by NewsLook.com
Panda Might Have Faked Pregnancy To Get Special Treatment

Panda Might Have Faked Pregnancy To Get Special Treatment

Newsy (Aug. 27, 2014) A panda in China showed pregnancy symptoms that disappeared after two months of observation. One theory: Her pseudopregnancy was a ploy for perks. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins