Featured Research

from universities, journals, and other organizations

Precisely targeted radiation controls sinus cancer with fewer side effects

Date:
November 7, 2010
Source:
Fox Chase Cancer Center
Summary:
Treating paranasal sinus cancer with three-dimensional radiation that conforms to the shape of the tumor -- a technique that minimizes side effects such as severe dry mouth and vision problems -- is safe and effective, new research shows.

Treating paranasal sinus cancer with three-dimensional radiation that conforms to the shape of the tumor -- a technique that minimizes side effects such as severe dry mouth and vision problems -- is safe and effective, research at Fox Chase Cancer Center shows. Aruna Turaka, M.D., radiation oncologist at Fox Chase, is presenting the results Nov. 2 at the annual meeting of the American Society for Radiation Oncology.

Located on either side of the nose, the paranasal sinuses are hollow, air-filled chambers lined with mucus-producing cells. Various types of cells in the sinuses can become malignant, and risk factors for the disease include being exposed to dust or certain chemicals in the workplace, smoking cigarettes.

"Due to the location of the sinuses, treating with radiation therapy by standard, conventional techniques is a challenge because it can cause side effects to the eyes and optic apparatus that eventually may lead to long-term complications," says Turaka. "Another concern is dry mouth due to radiation damage to the salivary glands."

Turaka and colleagues wanted to see if treating patients with intensity-modulated radiation therapy (IMRT) -- a method in which multiple beams of varying intensities are used to precisely radiate tumors while minimizing exposure to healthy, adjacent tissues -- is as effective as treating with standard radiation therapy. They studied a group of 31 patients with paranasal sinus cancers treated with IMRT at Fox Chase between May 2001 and June 2008. The patients did not receive additional radiation treatments to the lymph nodes, because paranasal sinus cancer usually does not spread to the lymph nodes.

The researchers found that IMRT controlled paranasal cancer just as well as regular radiation therapy, but with fewer serious side effects.

"In these patients, we did not see detrimental visual complications," Turaka says. "There were only minor side effects, such as dry eyes, which can be managed with tear supplements."

Similarly, patients treated with IMRT did not develop severe dry mouth.

"These results lead us to conclude that IMRT appears to be a safe and effective treatment for paranasal tumors," Turaka says.

In addition to Turaka, the paper's authors are Richard Cattaneo, M.D. of Temple University School of Medicine; Nicos Nicolaou, M.D. of Philadelphia Cancer Treatment Center; Steven Feigenberg, M.D. of the University of Maryland School of Medicine; and Tianyu Li, M.S., Eric Horwitz, M.D., Miriam Lango, M.D., Barbara Burtness, M.D., and John Ridge, M.D., Ph.D., FACS, all of Fox Chase Cancer Center.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Precisely targeted radiation controls sinus cancer with fewer side effects." ScienceDaily. ScienceDaily, 7 November 2010. <www.sciencedaily.com/releases/2010/11/101101093606.htm>.
Fox Chase Cancer Center. (2010, November 7). Precisely targeted radiation controls sinus cancer with fewer side effects. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/11/101101093606.htm
Fox Chase Cancer Center. "Precisely targeted radiation controls sinus cancer with fewer side effects." ScienceDaily. www.sciencedaily.com/releases/2010/11/101101093606.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins