Featured Research

from universities, journals, and other organizations

Juvenile arthritis: Etanercept helps restore normal growth in children with, study finds

Date:
November 4, 2010
Source:
Wiley - Blackwell
Summary:
Researchers observed a statistically significant increase in mean height, weight, and body mass index (BMI) percentiles in patients with juvenile idiopathic arthritis (JIA) who were treated with etanercept or etanercept plus methotrexate (MTX). JIA patients treated with MTX alone did not display an increase in growth percentiles.

Researchers from the Cincinnati Children's Hospital Medical Center observed a statistically significant increase in mean height, weight, and body mass index (BMI) percentiles in patients with juvenile idiopathic arthritis (JIA) who were treated with etanercept or etanercept plus methotrexate (MTX). JIA patients treated with MTX alone did not display an increase in growth percentiles.

Related Articles


Results of the 3-year study are available online and in the November issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

Juvenile idiopathic arthritis (JIA), one of the most common rheumatic diseases in children, causes significant pain and functional disability. According to a 2008 study by the National Arthritis Data Workgroup, there are close to 300,000 children in the U.S. with some form of juvenile arthritis. Prior studies show that JIA patients may experience impaired physical growth and development dependent upon the severity of chronic inflammation, longer duration of disease, and greater functional joint involvement.

"A realistic treatment goal for JIA patients should include therapy aimed at reducing inflammation in an effort to minimize disease-related disability and growth impairment," said lead author of the study Edward Giannini, DrPH, MSc. Dr. Giannini and colleagues conducted a 3-year, nonrandomized multi-center registry of 594 patients with polyarticular (90%) or systemic JIA who were treated with etanercept only, etanercept plus MTX, or MTX only.

Participants between the ages of 2 and 18 who enrolled in the registry were treated with etanercept twice weekly at a dose of 0.4 mg/kg or once weekly at a dose of 0.8 mg/kg. The height, weight, and BMI for each patient were recorded at baseline, years 1, 2, and 3, and compared with the U.S. Centers for Disease Control and Prevention standardized growth charts to obtain the percentiles.

The authors reported that the mean height in the etanercept group significantly increased by 4.8 percentile points by year 3. For those in the etanercept plus MTX group, a significant increase in mean height in years 1, 2, and 3 was also recorded -- 2.4, 3.3, and 5.6 percentile points, respectively. Similar significant increases in weight percentiles at years 1, 2 and 3, respectively, were observed in the etanercept-only group (7.4, 10.0, and 13.0) and in the etanercept plus MTX group (2.9, 6.9, and 8.4). BMI percentiles also increased significantly over the 3-year period, ranging from 9.6 to 13.8 percentile points in the etanercept-only group and from 2.1 to 5.2 percentile points in the etanercept plus MTX group.

"Studies have shown that growth retardation is associated with systemic inflammation and is a potentially permanent complication of JIA," explained Dr. Giannini. "Restoring normal growth development is a relevant goal of anti-inflammatory treatment in JIA patients and our study showed significant increases in height, weight, and BMI percentiles for those treated with etanercept alone or in combination with MTX." Significant changes in growth measures were not observed for patients receiving only MTX treatment.


Story Source:

The above story is based on materials provided by Wiley - Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Edward H. Giannini, Norman T. Ilowite, Daniel J. Lovell, Carol A. Wallace, C. Egla Rabinovich, Andreas Reiff, Gloria Higgins, Beth Gottlieb, Yun Chon, Nan Zhang, Scott W. Baumgartner. Effects of long-term etanercept treatment on growth in children with selected categories of juvenile idiopathic arthritis. Arthritis & Rheumatism, 2010; 62 (11): 3259 DOI: 10.1002/art.27682

Cite This Page:

Wiley - Blackwell. "Juvenile arthritis: Etanercept helps restore normal growth in children with, study finds." ScienceDaily. ScienceDaily, 4 November 2010. <www.sciencedaily.com/releases/2010/11/101103082308.htm>.
Wiley - Blackwell. (2010, November 4). Juvenile arthritis: Etanercept helps restore normal growth in children with, study finds. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2010/11/101103082308.htm
Wiley - Blackwell. "Juvenile arthritis: Etanercept helps restore normal growth in children with, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/11/101103082308.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins