Featured Research

from universities, journals, and other organizations

Anti-gout drug may decrease risk for colorectal adenoma progression

Date:
November 13, 2010
Source:
American Association for Cancer Research
Summary:
Allopurinol, a relatively inexpensive anti-gout medication that has been on the market for more than 20 years, may have some activity against colorectal adenomas, according to new research.

Allopurinol, a relatively inexpensive anti-gout medication that has been on the market for more than 20 years, may have some activity against colorectal adenomas, according to data presented at the Ninth Annual AACR Frontiers in Cancer Prevention Research Conference, held Nov. 7-10 in Philadelphia.

Specifically, the presence of a colorectal tumor tissue biomarker, Ki67, was markedly decreased in the preliminary results of a study of patients with colorectal polyps assigned to take allopurinol.

"Allopurinol has a well-known and good safety profile, and a cost of approximately one euro for one month of treatment," said Andrea De Censi, M.D., director, medical oncology unit, Galliera Hospital, Genoa, and advisor, division of cancer prevention and genetics, EIO, Milan, Italy.

"In the era of very expensive target-therapy in oncology, it is important to search for cheap agents that could be active in cancer prevention and thus have huge public health implications," he said.

In colorectal tumor tissue there are high levels of ROM, or reactive oxygen metabolites.

"These ROMs are thought to be important for development of tumor tissue and carcinogenesis. It is known today that ROMs activate crucial processes involved in cell growth, and in processes that inhibit programmed cell death, one of the main mechanisms involved in cancer control," De Censi said.

Therefore, researchers are testing the effect of ROM scavengers, such as allopurinol, to measure their effects on chemoprevention. According to De Censi, previous research from a large case-control study conducted in Israel showed that patients under chronic allopurinol use for gout had a lower risk for colorectal cancer than a matched control group not using allopurinol.

In the current study, De Censi and colleagues conducted a Phase I/II double-blind, placebo-controlled trial of patients with colorectal adenomatous polyps. Between 2006 and 2010, 73 patients were enrolled and assigned placebo or either a 100-mg or 300-mg dose of allopurinol for four to six weeks prior to removal of polyps.

They collected normal and adenomatous tissue samples and measured changes in the biomarker Ki67 in the normal tissue and the adenomatous tissue to measure the effect of allopurinol. At an interim analysis, conducted in November of 2008, only three mild adverse gastrointestinal events had occurred, confirming the high safety profile of allopurinol.

Tissue analysis in the first 13 patients indicated that levels of Ki67 in normal tissue had doubled in patients taking placebo, but had only increased by 5 percent in patients taking either dose of allopurinol.

In adenoma tissue, levels of Ki67 increased by 70 percent in patients taking placebo compared with only 6 percent in patients taking 100 mg allopurinol and 12 percent in patients taking 300 mg allopurinol.

"Our findings need to be confirmed on a larger number of subjects. However, if the positive trend noted on Ki67 is confirmed, we will conclude that allopurinol has some activity against colon carcinogenesis that may explain the favorable trend noted in the epidemiological studies. These results will provide the background for a large trial of adenoma recurrence reduction with allopurinol," De Censi said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Anti-gout drug may decrease risk for colorectal adenoma progression." ScienceDaily. ScienceDaily, 13 November 2010. <www.sciencedaily.com/releases/2010/11/101108140412.htm>.
American Association for Cancer Research. (2010, November 13). Anti-gout drug may decrease risk for colorectal adenoma progression. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2010/11/101108140412.htm
American Association for Cancer Research. "Anti-gout drug may decrease risk for colorectal adenoma progression." ScienceDaily. www.sciencedaily.com/releases/2010/11/101108140412.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins