Featured Research

from universities, journals, and other organizations

Nanopore array allows simultaneous tests in search for new drugs

Date:
November 10, 2010
Source:
Goethe University Frankfurt
Summary:
A novel nanopore array structure can be used to monitor the transport kinetics of membrane proteins by fluorescence microscopy. Due to the parallel design of the nanopore chip, a large number of samples can be analyzed simultaneously.

Membrane-associated receptors, channels and transporters are among the most important drug targets for the pharmaceutical industry. The search for new drugs resembles looking for a needle in a haystack. Therefore new analytical techniques are required which facilitate the simultaneous screening of a large library of compounds across a variety of membrane proteins.

However, this class of methods is still at the early stages of development. The group of Prof. Dr. Robert Tampι, in collaboration with the Walter Schottky Institute at Technical University Munich, has now presented a novel, automatable lab-on-chip device for high-throughput screening of sensitive membrane proteins.

The work is detailed in the journal Nano Letters, where the scientists describe the analysis of membrane proteins on a nano-fabricated chip surface that contains almost 50,000 nanopores. These pores are covered by a freely suspended lipid membrane that incorporates the proteins to be analyzed. Because the lipid membrane is free of organic solvents and the proteins do not touch the solid support, the fragile structure (and therefore function) of the proteins is preserved.

The system can be used to monitor the transport kinetics of membrane proteins by fluorescence microscopy. Due to the parallel design of the nanopore chip, a large number of samples can be analyzed simultaneously.


Story Source:

The above story is based on materials provided by Goethe University Frankfurt. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexander Kleefen, Daniel Pedone, Christian Grunwald, Ruoshan Wei, Matthias Firnkes, Gerhard Abstreiter, Ulrich Rant, Robert Tampé. Multiplexed Parallel Single Transport Recordings on Nanopore Arrays. Nano Letters, 2010; 101027134315070 DOI: 10.1021/nl1033528

Cite This Page:

Goethe University Frankfurt. "Nanopore array allows simultaneous tests in search for new drugs." ScienceDaily. ScienceDaily, 10 November 2010. <www.sciencedaily.com/releases/2010/11/101109095326.htm>.
Goethe University Frankfurt. (2010, November 10). Nanopore array allows simultaneous tests in search for new drugs. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/11/101109095326.htm
Goethe University Frankfurt. "Nanopore array allows simultaneous tests in search for new drugs." ScienceDaily. www.sciencedaily.com/releases/2010/11/101109095326.htm (accessed September 30, 2014).

Share This



More Matter & Energy News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) — More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
CERN Celebrates 60 Years of Science

CERN Celebrates 60 Years of Science

Reuters - Business Video Online (Sep. 29, 2014) — CERN, the European Organisation for Nuclear Research, celebrates 60 years of bringing nations together through science. As Joanna Partridge reports from inside the famous science centre it's also planning to turn the Large Hadron Collider particle accelerator back on after an upgrade. Video provided by Reuters
Powered by NewsLook.com
This 'Invisibility Cloak' Is Simpler Than Most

This 'Invisibility Cloak' Is Simpler Than Most

Newsy (Sep. 28, 2014) — Researchers from the University of Rochester have created a type of invisibility cloak with simple focal lenses. Video provided by Newsy
Powered by NewsLook.com
New Corvette Can Secretly Record Convos And Get You Arrested

New Corvette Can Secretly Record Convos And Get You Arrested

Newsy (Sep. 28, 2014) — The 2015 Corvette features valet mode – which allows the owner to secretly record audio and video – but in many states that practice is illegal. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins