Featured Research

from universities, journals, and other organizations

Alzheimer's disease: New study shows how amyloid beta disrupts one of the brain's anti-oxidant proteins, points way to protect it

Date:
November 9, 2010
Source:
University of California - San Diego
Summary:
A new study shows that amyloid beta disrupts one of the brain's anti-oxidant proteins and demonstrates a way to protect that protein, and perhaps others, from amyloid's harmful effects.

Clear strands of toxic aggregated amyloid beta peptides, a hallmark of Alzheimer's disease, interact with proteins such as the anti-oxidant enzyme catalase, shown in red. The interaction disables catalase, resulting in oxidative damage to neural cells in culture. Protein-resistant coating (blue) on the aggregated amyloids inhibit these harmful interactions and protect of cells from amyloid beta-induced oxidative stress and toxicity.
Credit: Christopher Burke for UC San Diego

Researchers suspect that a protein superstructure called amyloid beta is responsible for much of the neural damage of Alzheimer's disease.

A new study at the University of California, San Diego, shows that amyloid beta disrupts one of the brain's anti-oxidant proteins and demonstrates a way to protect that protein, and perhaps others, from amyloid's harmful effects.

"Amyloid seems to cause damage to cells," said chemistry professor Jerry Yang. "We have reported in a very detailed way one potential interaction of how amyloid can cause disease, and we found a way to stop it." His group's report of their results will appear in the Journal of Biological Chemistry in December.

Their study focused on catalase, an enzyme that mops up excess oxidants, because catalase normally helps to prevent the kind of damage seen in the brains of patients with Alzheimer's disease and previous work had found catalase proteins deposited within amyloid plaques.

Lila Habib, a bioengineering graduate student and the first author of the report, added amyloid to cultured neural cells and looked at its effects.

"We were able to determine that amyloid beta and this anti-oxidant enzyme, catalase, interact, and that this interaction harmed catalase so it wasn't able to perform its physiological function: to degrade hydrogen peroxide into oxygen and water," she said.

When Habib coated the amyloid with a small molecule designed to prevent its interaction with other proteins, she was able to restore the activity of catalase and return hydrogen peroxide to normal levels within the cells.

The coating Habib used to probe the interaction between amyloid and catalase is a candidate drug -- one of a class of molecules that Yang's lab has developed.

"Not only are we learning more about the disease, but we are also developing a potential strategy for treatment," said Yang, who is currently testing the new approach in a mouse model of the disease.

Michelle Lee, an undergraduate chemistry student, synthesized the amyloid-coating molecule and is a co-author of the article.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. S. Olsen, C. Brown, C. C. Capule, M. Rubinshtein, T. M. Doran, R. K. Srivastava, C. Feng, B. L. Nilsson, J. Yang, S. Dewhurst. Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)- and Semen-mediated Enhancement of HIV-1 Infection. Journal of Biological Chemistry, 2010; 285 (46): 35488 DOI: 10.1074/jbc.M110.163659

Cite This Page:

University of California - San Diego. "Alzheimer's disease: New study shows how amyloid beta disrupts one of the brain's anti-oxidant proteins, points way to protect it." ScienceDaily. ScienceDaily, 9 November 2010. <www.sciencedaily.com/releases/2010/11/101109095431.htm>.
University of California - San Diego. (2010, November 9). Alzheimer's disease: New study shows how amyloid beta disrupts one of the brain's anti-oxidant proteins, points way to protect it. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/11/101109095431.htm
University of California - San Diego. "Alzheimer's disease: New study shows how amyloid beta disrupts one of the brain's anti-oxidant proteins, points way to protect it." ScienceDaily. www.sciencedaily.com/releases/2010/11/101109095431.htm (accessed October 22, 2014).

Share This



More Mind & Brain News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
Portable Breathalyzer Gets You Home Safely

Portable Breathalyzer Gets You Home Safely

Buzz60 (Oct. 21, 2014) Breeze, a portable breathalyzer, gets you home safely by instantly showing your blood alcohol content, and with one tap, lets you call an Uber, a cab or a friend from your contact list to pick you up. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Movies Might Desensitize Violence For Parents, Not Just Kids

Movies Might Desensitize Violence For Parents, Not Just Kids

Newsy (Oct. 20, 2014) A study suggests that parents become desensitized to violent movies as well as children, which leads them to allow their kids to view violent films. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins