Featured Research

from universities, journals, and other organizations

Study examines relationship between autoimmune skin disease and neurologic disorders

Date:
February 11, 2011
Source:
JAMA and Archives Journals
Summary:
Individuals with the autoimmune skin disease bullous pemphigoid appear more likely to have a diagnosis of neurologic disease, such as dementia and cerebrovascular disease, according to a new report.

Individuals with the autoimmune skin disease bullous pemphigoid appear more likely to have a diagnosis of neurologic disease, such as dementia and cerebrovascular disease, according to a report in the November issue of Archives of Dermatology, one of the JAMA/Archives journals.

Related Articles


"Bullous pemphigoid is a debilitating autoimmune skin disease that is characterized by large, tense blisters on the skin of the elderly," the authors write as background information in the article. The condition affects about 43 per million individuals per year in the United Kingdom and 7 to 13 per million in other parts of Europe. "Over the last two decades, various neurologic diseases have been described in association with bullous pemphigoid, including cerebrovascular disease, dementia, multiple sclerosis, epilepsy, Parkinson disease, Shy-Drager syndrome and amyotrophic lateral sclerosis."

Kathy Taghipour, M.D., M.R.C.P., of Oxford Radcliffe Hospitals, Oxford, England, and colleagues assessed 90 consecutive patients with bullous pemphigoid and 141 controls without the condition. Medical histories were reviewed for the presence of neurologic disease, defined as a confirmed diagnosis by a hospital physician; positive imaging findings; or considerable functional disability due to mental impairment.

Among patients with bullous pemphigoid, 42 (46 percent) had at least one neurologic disease, compared with 16 controls (11 percent). Four major neurologic diseases were observed among these patients: cerebrovascular disease, dementia, Parkinson's disease and epilepsy. However, only rates of cerebrovascular disease and dementia were significantly greater among patients than among controls.

Of the 36 patients with accurate information about the timing of their diagnoses, bullous pemphigoid was diagnosed after neurologic disease in most (26 of 36 or 72 percent), with a median (midpoint) time of 5.5 years between diagnoses.

"Neurologic symptoms may often be subtle, and the onset of disease may be insidious, leading to diagnostic delay," the authors write. "It is therefore likely that the interval between neurologic disease and bullous pemphigoid is longer than estimated, and it is tempting to speculate that certain neurologic conditions can predispose to bullous pemphigoid." The association could be explained by an immunologic cross-reactivity between the skin and the brain, in which neurologic disorders trigger an immune response that affects the skin, the authors note.

"The relationship between bullous pemphigoid and neurologic disease has been the subject of numerous case reports, but epidemiological data are scarce, and this subgroup of patients with bullous pemphigoid have not been further characterized," they conclude. "We have demonstrated that there is a significant association between bullous pemphigoid and neurologic disorders, in particular cerebrovascular disease and dementia, and that neurologic disease may be a predisposing factor for bullous pemphigoid. The mechanism by which neurologic disease may trigger bullous pemphigoid remains obscure and requires further investigation."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kathy Taghipour; Ching-Chi Chi; Angela Vincent; Richard W. Groves; Vanessa Venning; Fenella Wojnarowska. The Association of Bullous Pemphigoid With Cerebrovascular Disease and Dementia: A Case-Control Study. Archives of Dermatology, 2010; 146 (11): 1251-1254 DOI: 10.1001/archdermatol.2010.322

Cite This Page:

JAMA and Archives Journals. "Study examines relationship between autoimmune skin disease and neurologic disorders." ScienceDaily. ScienceDaily, 11 February 2011. <www.sciencedaily.com/releases/2010/11/101115174015.htm>.
JAMA and Archives Journals. (2011, February 11). Study examines relationship between autoimmune skin disease and neurologic disorders. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/11/101115174015.htm
JAMA and Archives Journals. "Study examines relationship between autoimmune skin disease and neurologic disorders." ScienceDaily. www.sciencedaily.com/releases/2010/11/101115174015.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins