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Nerve cell molecule has antidepressant effect; animal study may lead to more effective treatments for depression

Date:
January 31, 2011
Source:
Society for Neuroscience
Summary:
Mice that lack a molecule involved in regulating nerve cell signaling are more active and resilient to stressful situations, a new study shows. Mice lacking the molecule -- known as Cdk5 -- exhibited the same behaviors seen in mice given antidepressant drugs.

Mice that lack a molecule involved in regulating nerve cell signaling are more active and resilient to stressful situations, a new study shows. The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

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Mice lacking the molecule -- known as Cdk5 -- exhibited the same behaviors seen in mice given antidepressant drugs.

"We immediately realized that these mice could teach us something important about depression and that we could use them to study new pathways that might serve as targets to treat the disease," said senior author James Bibb, PhD, of the University of Texas Southwestern Medical Center, who directed the study.

When dopamine and serotonin, brain chemicals involved in mood regulation, act at brain cells, a "wave" of the signaling molecule cyclic adenosine monophosphate (cyclic AMP) is generated. Normally, another molecule, phosphodiesterase, breaks down the cyclic AMP. However, Bibb and his colleagues discovered that phosphodiesterase did not do its job -- the wave of cyclic AMP did not stop -- in mice that lacked Cdk5. Without Cdk5, the mice behaved with more resilience to stress and showed strong antidepressant-like behavior. The discovery that Cdk5 regulates phosphodiesterases opens up new opportunities to target them.

"Our hope is that the conceptual advances these findings represent will contribute to the development of new depression therapeutics," Bibb said.

Research was supported by the National Institute of Mental Health, the National Institute on Drug Addiction, and the Department of Psychiatry at the University of Texas Southwestern Medical Center.


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The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Nerve cell molecule has antidepressant effect; animal study may lead to more effective treatments for depression." ScienceDaily. ScienceDaily, 31 January 2011. <www.sciencedaily.com/releases/2010/11/101116101947.htm>.
Society for Neuroscience. (2011, January 31). Nerve cell molecule has antidepressant effect; animal study may lead to more effective treatments for depression. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2010/11/101116101947.htm
Society for Neuroscience. "Nerve cell molecule has antidepressant effect; animal study may lead to more effective treatments for depression." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116101947.htm (accessed January 25, 2015).

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