Featured Research

from universities, journals, and other organizations

Melatonin temporarily improves dialysis patients' sleep

Date:
November 21, 2010
Source:
American Society of Nephrology
Summary:
Sleep disorders are common in kidney disease patients on dialysis due to a disturbance in their biological clocks. Researchers previously found that giving dialysis patients melatonin, a hormone that helps regulate sleep and wake cycles, can improve sleep over a short period of time. Now, these researchers have investigated whether the benefits of melatonin on sleep persist over the long term, and if long-term use of melatonin could improve patients' quality of life.

Sleep disorders are common in kidney disease patients on dialysis due to a disturbance in their biological clocks. Marije Russcher, PharmD, Birgit Koch, PharmD, PhD, (Meander Medical Center, in Amersfoort, the Netherlands) and colleagues previously found that giving dialysis patients melatonin, a hormone that helps regulate sleep and wake cycles, can improve sleep over a short period of time.

Related Articles


Now, these researchers have investigated whether the benefits of melatonin on sleep persist over the long term, and if long-term use of melatonin could improve patients' quality of life. 70 dialysis patients received melatonin or a placebo for 1 year. At 3 months, the previously shown beneficial effect of the short-term use of melatonin on sleep onset was confirmed.

The investigators also noted improvement of sleep efficiency and sleep time. In contrast, at 12 months none of the measured sleep parameters differed significantly from placebo. Regarding quality of life, melatonin had a positive effect on social functioning and a trend in improvement of mentality. "We confirmed the short term beneficial effects of melatonin on sleep; however, we found no indication that these beneficial effects persist in long-term usage of melatonin," said Ms. Russcher. "Further research should focus on optimizing melatonin dosage and time of dosing, specifically in kidney patients."

Study co-authors include Ernst Hagen, MD, PhD, Elsbeth Nagtegaal, PharmD, PhD, Monique van der Westerlaken, PharmD (Meander Medical Center, in Amersfoort, the Netherlands); Carlo Gaillard, MD, PhD (Meander Medical Center, in Amersfoort and the VU Medical Center, in Amsterdam, the Netherlands); Frans van Ittersum, MD, PhD and Pieter M. Ter Wee, MD, PhD (the VU Medical Center, in Amsterdam, the Netherlands), Wim van Dorp, MD, PhD (Kennemer Hospital, in Haarlem, the Netherlands), Bas Gabreλls, MD, PhD (Rijnland Hospital, in Leiderdorp, the Netherlands)

Dr. Ter Wee receives research support from Abbott, Baxter, Gambro, Fresenius, and Roche and honoraria from Amgen, Roche, Genzyme, and Fresenius.

The study abstract, "The Long-Term Effects of Melatonin on Sleep and Quality of Life in Hemodialysis Patients," [SA-PO2333] was presented as a poster on November 20, 2010 at the Colorado Convention Center in Denver, CO.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Nephrology. "Melatonin temporarily improves dialysis patients' sleep." ScienceDaily. ScienceDaily, 21 November 2010. <www.sciencedaily.com/releases/2010/11/101121122537.htm>.
American Society of Nephrology. (2010, November 21). Melatonin temporarily improves dialysis patients' sleep. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2010/11/101121122537.htm
American Society of Nephrology. "Melatonin temporarily improves dialysis patients' sleep." ScienceDaily. www.sciencedaily.com/releases/2010/11/101121122537.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins