Featured Research

from universities, journals, and other organizations

Melatonin temporarily improves dialysis patients' sleep

Date:
November 21, 2010
Source:
American Society of Nephrology
Summary:
Sleep disorders are common in kidney disease patients on dialysis due to a disturbance in their biological clocks. Researchers previously found that giving dialysis patients melatonin, a hormone that helps regulate sleep and wake cycles, can improve sleep over a short period of time. Now, these researchers have investigated whether the benefits of melatonin on sleep persist over the long term, and if long-term use of melatonin could improve patients' quality of life.

Sleep disorders are common in kidney disease patients on dialysis due to a disturbance in their biological clocks. Marije Russcher, PharmD, Birgit Koch, PharmD, PhD, (Meander Medical Center, in Amersfoort, the Netherlands) and colleagues previously found that giving dialysis patients melatonin, a hormone that helps regulate sleep and wake cycles, can improve sleep over a short period of time.

Related Articles


Now, these researchers have investigated whether the benefits of melatonin on sleep persist over the long term, and if long-term use of melatonin could improve patients' quality of life. 70 dialysis patients received melatonin or a placebo for 1 year. At 3 months, the previously shown beneficial effect of the short-term use of melatonin on sleep onset was confirmed.

The investigators also noted improvement of sleep efficiency and sleep time. In contrast, at 12 months none of the measured sleep parameters differed significantly from placebo. Regarding quality of life, melatonin had a positive effect on social functioning and a trend in improvement of mentality. "We confirmed the short term beneficial effects of melatonin on sleep; however, we found no indication that these beneficial effects persist in long-term usage of melatonin," said Ms. Russcher. "Further research should focus on optimizing melatonin dosage and time of dosing, specifically in kidney patients."

Study co-authors include Ernst Hagen, MD, PhD, Elsbeth Nagtegaal, PharmD, PhD, Monique van der Westerlaken, PharmD (Meander Medical Center, in Amersfoort, the Netherlands); Carlo Gaillard, MD, PhD (Meander Medical Center, in Amersfoort and the VU Medical Center, in Amsterdam, the Netherlands); Frans van Ittersum, MD, PhD and Pieter M. Ter Wee, MD, PhD (the VU Medical Center, in Amsterdam, the Netherlands), Wim van Dorp, MD, PhD (Kennemer Hospital, in Haarlem, the Netherlands), Bas Gabreλls, MD, PhD (Rijnland Hospital, in Leiderdorp, the Netherlands)

Dr. Ter Wee receives research support from Abbott, Baxter, Gambro, Fresenius, and Roche and honoraria from Amgen, Roche, Genzyme, and Fresenius.

The study abstract, "The Long-Term Effects of Melatonin on Sleep and Quality of Life in Hemodialysis Patients," [SA-PO2333] was presented as a poster on November 20, 2010 at the Colorado Convention Center in Denver, CO.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Nephrology. "Melatonin temporarily improves dialysis patients' sleep." ScienceDaily. ScienceDaily, 21 November 2010. <www.sciencedaily.com/releases/2010/11/101121122537.htm>.
American Society of Nephrology. (2010, November 21). Melatonin temporarily improves dialysis patients' sleep. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2010/11/101121122537.htm
American Society of Nephrology. "Melatonin temporarily improves dialysis patients' sleep." ScienceDaily. www.sciencedaily.com/releases/2010/11/101121122537.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) — Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) — AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) — A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins