Featured Research

from universities, journals, and other organizations

Cancer: Thermotherapy as a chemotherapy alternative?

Date:
November 24, 2010
Source:
Virginia Tech
Summary:
Using hyperthermia, engineering researchers unveiled a new method to target and destroy cancerous cells. The treatment uses hyperthermia to elevate the temperature of tumor cells, while keeping the surrounding healthy tissue at a lower degree of body heat. The investigators used both in vitro and in vivo experiments to confirm their findings.

Using hyperthermia, Virginia Tech engineering researchers and a colleague from India unveiled a new method to target and destroy cancerous cells. The research was presented at the 63rd annual meeting of the American Physical Society Nov. 23 in Long Beach, Calif.

The cancer treatment uses hyperthermia to elevate the temperature of tumor cells, while keeping the surrounding healthy tissue at a lower degree of body heat. The investigators used both in vitro and in vivo experiments to confirm their findings.

The collaborators are Monrudee Liangruksa, a Virginia Tech graduate student in engineering science and mechanics, and her thesis adviser, Ishwar Puri, professor and head of the department, along with Ranjan Ganguly of the department of power engineering at Iadavpur Univesity, Kolkata, India.

Liangruska of Bangkok, Thailand, presented the paper at the meeting.

In an interview prior to the presentation, Puri explained that to further perfect the technique they used ferrofluids to induce the hyperthermia. A ferrofluid is a liquid that becomes strongly magnetized in the presence of a magnetic field. The magnetic nanoparticles are suspended in the non-polar state.

"These fluids can then be magnetically targeted to cancerous tissues after intravenous application," Puri said. "The magnetic nanoparticles, each billionths of a meter in size, seep into the tissue of the tumor cell due to the high permeability of these vessels."

Afterwards, the magnetic nanoparticles are heated by exposing the tumor to a high frequency alternating magnetic field, causing the tissue's death by heating. This process is called magnetic fluid hyperthermia and they have nicknamed it thermotherapy.

Temperatures in the range of 41 to 45 degrees Celsius are enough to slow or halt the growth of cancerous tissue. However, without the process of magnetic fluid hyperthermia, these temperatures also destroy healthy cells.

"The ideal hyperthermia treatment sufficiently increases the temperature of the tumor cells for about 30 minutes while maintaining the healthy tissue temperature below 41 degrees Celsius," Puri said. "Our ferrofluid-based thermotherapy can be also accomplished through thermoablation, which typically heats tissues up to 56 degrees C to cause their death, coagulation, or carbonization by exposure to a noninvasive radio frequency, alternating current magnetic field. Local heat transfer from the nanoparticles increases the tissue temperature and ruptures the cell membranes."

Puri added that testing showed iron oxide nanoparticles are "the most biocompatible agents for magnetic fluid hyperthermia." Platinum and nickel also act as magnetic nanoparticles but they "are toxic and vulnerable" when exposed to oxygen.

The researchers plan to test their analytical approach by conducting experiments on various cancer cells in collaboration with Dr. Elankumaran Subbiah of the Virginia-Maryland School of Veterinary Medicine. A senior design team consisting of five engineering science and mechanics undergraduate Virginia Tech students is fabricating an apparatus for these tests.


Story Source:

The above story is based on materials provided by Virginia Tech. Note: Materials may be edited for content and length.


Cite This Page:

Virginia Tech. "Cancer: Thermotherapy as a chemotherapy alternative?." ScienceDaily. ScienceDaily, 24 November 2010. <www.sciencedaily.com/releases/2010/11/101123095639.htm>.
Virginia Tech. (2010, November 24). Cancer: Thermotherapy as a chemotherapy alternative?. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2010/11/101123095639.htm
Virginia Tech. "Cancer: Thermotherapy as a chemotherapy alternative?." ScienceDaily. www.sciencedaily.com/releases/2010/11/101123095639.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins