Featured Research

from universities, journals, and other organizations

New targets for treatment of diarrheal diseases

Date:
November 30, 2010
Source:
Royal College of Surgeons in Ireland (RCSI)
Summary:
A potential new target has been uncovered for the treatment of a range of intestinal diseases that are associated with diarrhea. Current medications are often ineffective and can have serious side effects so this discovery gives hope for the development of new treatments for sufferers of intestinal disease.

Joseph Ward, lead author of the study, at work in the RCSI Molecular Medicine Laboratory.
Credit: Image courtesy of Royal College of Surgeons in Ireland (RCSI)

A study by researchers in the Royal College of Surgeons in Ireland (RCSI) has uncovered a potential new target for the treatment of a range of intestinal diseases that are associated with diarrhea. Current medications are often ineffective and can have serious side effects so this discovery gives hope for the development of new treatments for sufferers of intestinal disease.

Worldwide, almost 2 million children die each year as a result of infectious diarrhea, however, diarrheal diseases are also very common in developed countries. "Diarrhea associated intestinal disorders, such as irritable bowel syndrome (IBS), Crohn's disease, colitis, coeliac disease and microbial infections are a major health issue in Ireland. It is estimated that between 40,000 and 50,000 people visit their local Gastroenterology clinic each year seeking treatment for diarrhea. The cost to the Irish economy in terms of healthcare costs and lost working days is immense," commented Dr Stephen Keely, senior author on the study and Associate Director of the RCSI Molecular Medicine Lab at Beaumont Hospital.

Explaining the findings of the research study, Dr Keely said: 'Current treatments for intestinal diseases are not targeted specifically enough and as a result can be ineffective or have serious side effects. Working with researchers in UCD and TCD, we have discovered that a type of protein, known as hydroxylases, play a key role in regulating water and salt transport in the intestines. Our experimental results suggest that by inhibiting the activity of these proteins, diarrhea can be prevented. The discovery gives us a promising new target for the development of drugs to treat intestinal diseases that have diarrhea as a primary symptom. Because such drugs would act directly on the cells responsible for controlling water movement in the intestine, they would potentially have better outcomes and reduced side effects for patients," Dr Keely concluded.

The lead author on the paper is Joseph Ward who conducted the research as part of his PhD studies along with Dr Karen Lawler and Dr Keely from the Molecular Medicine Laboratories in RCSI. The team also collaborated with Prof Padraic Fallon from the Institute of Molecular Medicine, Trinity College Dublin, and Prof Cormac Taylor of the Conway Institute at University College Dublin.

This work was funded by Science Foundation Ireland and the Higher Education Authority's Programme for Research in Third Level Institutions (PRTLI) Cycle 4, as part of the National Biophotonics Imaging Platform (NBIP) Ireland.


Story Source:

The above story is based on materials provided by Royal College of Surgeons in Ireland (RCSI). Note: Materials may be edited for content and length.


Journal Reference:

  1. J. B. J. Ward, K. Lawler, S. Amu, C. T. Taylor, P. G. Fallon, S. J. Keely. Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. The FASEB Journal, 2010; DOI: 10.1096/fj.10-166983

Cite This Page:

Royal College of Surgeons in Ireland (RCSI). "New targets for treatment of diarrheal diseases." ScienceDaily. ScienceDaily, 30 November 2010. <www.sciencedaily.com/releases/2010/11/101130005635.htm>.
Royal College of Surgeons in Ireland (RCSI). (2010, November 30). New targets for treatment of diarrheal diseases. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/11/101130005635.htm
Royal College of Surgeons in Ireland (RCSI). "New targets for treatment of diarrheal diseases." ScienceDaily. www.sciencedaily.com/releases/2010/11/101130005635.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins