A study by researchers in the Royal College of Surgeons in Ireland (RCSI) has uncovered a potential new target for the treatment of a range of intestinal diseases that are associated with diarrhea. Current medications are often ineffective and can have serious side effects so this discovery gives hope for the development of new treatments for sufferers of intestinal disease.
Worldwide, almost 2 million children die each year as a result of infectious diarrhea, however, diarrheal diseases are also very common in developed countries. "Diarrhea associated intestinal disorders, such as irritable bowel syndrome (IBS), Crohn's disease, colitis, coeliac disease and microbial infections are a major health issue in Ireland. It is estimated that between 40,000 and 50,000 people visit their local Gastroenterology clinic each year seeking treatment for diarrhea. The cost to the Irish economy in terms of healthcare costs and lost working days is immense," commented Dr Stephen Keely, senior author on the study and Associate Director of the RCSI Molecular Medicine Lab at Beaumont Hospital.
Explaining the findings of the research study, Dr Keely said: 'Current treatments for intestinal diseases are not targeted specifically enough and as a result can be ineffective or have serious side effects. Working with researchers in UCD and TCD, we have discovered that a type of protein, known as hydroxylases, play a key role in regulating water and salt transport in the intestines. Our experimental results suggest that by inhibiting the activity of these proteins, diarrhea can be prevented. The discovery gives us a promising new target for the development of drugs to treat intestinal diseases that have diarrhea as a primary symptom. Because such drugs would act directly on the cells responsible for controlling water movement in the intestine, they would potentially have better outcomes and reduced side effects for patients," Dr Keely concluded.
The lead author on the paper is Joseph Ward who conducted the research as part of his PhD studies along with Dr Karen Lawler and Dr Keely from the Molecular Medicine Laboratories in RCSI. The team also collaborated with Prof Padraic Fallon from the Institute of Molecular Medicine, Trinity College Dublin, and Prof Cormac Taylor of the Conway Institute at University College Dublin.
This work was funded by Science Foundation Ireland and the Higher Education Authority's Programme for Research in Third Level Institutions (PRTLI) Cycle 4, as part of the National Biophotonics Imaging Platform (NBIP) Ireland.
- J. B. J. Ward, K. Lawler, S. Amu, C. T. Taylor, P. G. Fallon, S. J. Keely. Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. The FASEB Journal, 2010; DOI: 10.1096/fj.10-166983
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