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Organ size is determined by p53 protein

Date:
December 16, 2010
Source:
Institute for Research in Biomedicine-IRB
Summary:
In studies conducted on the fruit fly, researchers have revealed that organs have the molecular mechanisms to control their proportions. In this process the protein p53 plays a crucial role.

Flies with wings of different sizes but in proportion.
Credit: Copyright Milán Lab, IRB Barcelona.

In studies conducted on the fruit fly, researchers at IRB Barcelona headed by ICREA Professor Marco Milán have revealed that organs have the molecular mechanisms to control their proportions. In this process the protein p53 plays a crucial role. The study was published December 15 in the journal PLoS Biology.

The correct establishment of organ proportions, which occurs during embryonic development, is vital for the proper function of all organisms. Alterations in the mechanisms responsible for these processes cause fatal errors in embryos and even cause their death. In the Renaissance period, Leonardo da Vinci, in his famous picture of the "Vitruvian man," reflects the importance of the size of the human beings and of the organs it holds.

Hormones, such as insulin and steroidal hormones, contribute to maintaining this equilibrium. "What we have demonstrated is that the organs themselves also have the mechanisms to maintain a balance of shapes and to grow in a coordinated fashion," states Milán.

Organs have 'decision-making' capability

The tumour suppressor protein p53 is activated in response to stress, such as that caused by oncogenic mutations, chemical agents or physical stimuli like ultraviolet radiation. This protein induces the death of those cells in which the stress has caused irreversible damage and that can become cancerous. In addition, p53 impedes the proliferation of cells that have self-repairing capacity. In this study the researchers used the wing primordium of the fruit fly "Drosophila melanogaster" as a model. The primordium is responsible for forming the adult wing and was used to study how this stress affects remaining healthy tissue.

Headed by Milán, the study shows that when some specific cells of the wing primordium are subjected to stress, not only is the growth of this part of the organ reduced but also that of the remaining section. As a result, adult flies have smaller but proportional wings. "These experiments indicate that stressed cells send signals to the remaining tissues in order to reduce their growth in order to allow damaged tissue to repair itself and allow the organ to grow in a coordinated manner," explains Milán. When p53 was suppressed in stressed cells, the resulting wings were disproportional. This observation indicates that this protein is crucial for the coordinated growth of the different parts of an organ. Again, nature dictates that size is not relevant but proportions are.


Story Source:

The above story is based on materials provided by Institute for Research in Biomedicine-IRB. Note: Materials may be edited for content and length.


Journal Reference:

  1. Duarte Mesquita, Andrés Dekanty, Marco Milán. A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila. PLoS Biology, 2010; 8 (12): e1000566 DOI: 10.1371/journal.pbio.1000566

Cite This Page:

Institute for Research in Biomedicine-IRB. "Organ size is determined by p53 protein." ScienceDaily. ScienceDaily, 16 December 2010. <www.sciencedaily.com/releases/2010/12/101215083223.htm>.
Institute for Research in Biomedicine-IRB. (2010, December 16). Organ size is determined by p53 protein. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/12/101215083223.htm
Institute for Research in Biomedicine-IRB. "Organ size is determined by p53 protein." ScienceDaily. www.sciencedaily.com/releases/2010/12/101215083223.htm (accessed April 18, 2014).

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