Featured Research

from universities, journals, and other organizations

Blood pressure control system found in kidney's structural units

Date:
March 28, 2011
Source:
University of Texas Health Science Center at San Antonio
Summary:
A new finding shows how the million working units in the kidney regulate salt handling. This identifies a new possible therapeutic target for treating high blood pressure.

A new finding shows how the million working units in the kidney regulate salt handling. This identifies a new possible therapeutic target for treating high blood pressure. The kidney is made up of roughly 1 million working units called nephrons. These basic structural units remove waste products from the blood, recycle some substances to be reused and eliminate what is left as urine. The end segment of nephrons, called the distal nephron, helps set blood pressure by controlling the amount of sodium in our blood.

Related Articles


Scientists at The University of Texas Health Science Center San Antonio have reported how this essential function of the distal nephron is regulated. They demonstrated that sodium handling by the distal nephron is under the control of a local regulatory system.

Loss or dysfunction of this system leads to hypertension resulting from improper salt retention by the kidneys, the scientists found in mouse studies.

"These studies provide the first unequivocal evidence of a blood pressure control system in the distal nephron of the kidney," said senior author James Stockand, Ph.D., professor of physiology at the Health Science Center. "It turns out control of sodium re-absorption by this system is as important to normal blood pressure regulation as is a better-understood system, called the renin-angiotensin-aldosterone system, which works outside the kidney."

Many medications that treat high blood pressure target salt handling in the kidney. "Our work identifies a possible new therapeutic target," Dr. Stockand said.

The research was funded by the U.S. National Institutes of Health and American Heart Association and included colleagues at the University of Southern California. The findings are in the Jan. 14 issue of the Journal of Biological Chemistry.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Mironova, J. Peti-Peterdi, V. Bugaj, J. D. Stockand. Diminished Paracrine Regulation of the Epithelial Na Channel by Purinergic Signaling in Mice Lacking Connexin 30. Journal of Biological Chemistry, 2010; 286 (2): 1054 DOI: 10.1074/jbc.M110.176552

Cite This Page:

University of Texas Health Science Center at San Antonio. "Blood pressure control system found in kidney's structural units." ScienceDaily. ScienceDaily, 28 March 2011. <www.sciencedaily.com/releases/2011/01/110114164519.htm>.
University of Texas Health Science Center at San Antonio. (2011, March 28). Blood pressure control system found in kidney's structural units. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2011/01/110114164519.htm
University of Texas Health Science Center at San Antonio. "Blood pressure control system found in kidney's structural units." ScienceDaily. www.sciencedaily.com/releases/2011/01/110114164519.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins