Featured Research

from universities, journals, and other organizations

New method to correct mortality rate biases in HIV treatment programs

Date:
January 18, 2011
Source:
Public Library of Science
Summary:
HIV treatment programs in sub-Saharan Africa should routinely report mortality rates among patients who remain in the programs and those patients lost to follow-up, according to a study by researchers from the International Epidemiologic Databases to Evaluate AIDS in East Africa, Western Africa and Southern Africa.

HIV treatment programs in sub-Saharan Africa should routinely report mortality rates among patients who remain in the programs and those patients lost to follow-up, according to a study by Matthias Egger and colleagues from the International Epidemiologic Databases to Evaluate AIDS in East Africa, Western Africa, and Southern Africa that is published in this week's PLoS Medicine.

As a substantial proportion of patients in HIV treatment programs are lost to follow-up, mortality estimates for patients in these programs can be severely underestimated, so this bias needs to be taken into account when comparing the effectiveness of different programs.

The authors arrived at these conclusions by developing a nomogram (calculator) that corrects mortality estimates for loss to follow-up, based on the fact that mortality of all patients starting antiretroviral therapy in an HIV treatment program is a weighted average of mortality among patients lost to follow-up and patients remaining in care.

In an accompanying Perspective, Gregory Bisson from the University of Pennsylvania School of Medicine (not involved in the research) comments that "currently we know little about the biology and behaviors that underlie loss to follow-up, but with 5.2 million people on [antiretroviral therapy], and more starting soon as a result of the 2010 WHO guidelines recommending HIV treatment earlier during disease progression, a greater understanding of loss to follow-up in its various forms is needed in order to keep the HIV treatment effort on track." He adds, "by addressing the effects of loss to follow-up on programmatic mortality estimates, and by providing monitoring efforts with a useful new tool, Egger and colleagues have helped address this need."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal References:

  1. Egger M, Spycher BD, Sidle J, Weigel R, Geng EH, et al. Correcting Mortality for Loss to Follow-Up: A Nomogram Applied to Antiretroviral Treatment Programmes in Sub-Saharan Africa. PLoS Medicine, 2011; 8 (1): e1000390 DOI: 10.1371/journal.pmed.1000390
  2. Bisson GP. A Simple Novel Method for Determining Mortality Rates in HIV Treatment Programs Worldwide. , 2011; 8 (1): e1000392 DOI: 10.1371/journal.pmed.1000392

Cite This Page:

Public Library of Science. "New method to correct mortality rate biases in HIV treatment programs." ScienceDaily. ScienceDaily, 18 January 2011. <www.sciencedaily.com/releases/2011/01/110118180519.htm>.
Public Library of Science. (2011, January 18). New method to correct mortality rate biases in HIV treatment programs. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2011/01/110118180519.htm
Public Library of Science. "New method to correct mortality rate biases in HIV treatment programs." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118180519.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins