Featured Research

from universities, journals, and other organizations

Mammograms: Detecting more than breast cancer, may help assess heart risk in kidney disease patients

Date:
January 22, 2011
Source:
American Society of Nephrology
Summary:
Routine mammograms performed for breast cancer screening could serve another purpose as well: detecting calcifications in the blood vessels of patients with advanced kidney disease, according to a new study.

Routine mammograms can show arterial calcium deposits -- which may contribute to heart disease risk.

Routine mammograms performed for breast cancer screening could serve another purpose as well: detecting calcifications in the blood vessels of patients with advanced kidney disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

Mammograms show calcium deposits in the breast arteries in nearly two-thirds of women with end-stage renal disease (ESRD), according to the study by W. Charles O'Neill, MD (Emory University, Atlanta). "Breast arterial calcification is a specific and useful marker of medial vascular calcification in chronic kidney disease (CKD), and its prevalence is markedly increased in ESRD and advanced CKD," the researchers write.

Arterial calcium deposits may contribute to the high rate of death from heart disease in patients with CKD and ESRD. In addition to calcifications of the inner or "intimal" layer of the blood vessels (atherosclerosis), calcifications can also occur in the middle, or "medial" layer. These medial calcium deposits may contribute to cardiovascular disease risk by making the arteries stiffer, but they can be difficult to detect.

In an initial study, Dr. O'Neill and colleagues examined samples of breast artery tissue from 16 women with kidney disease. While all of the samples showed medial calcifications of the breast artery, none showed intimal calcifications.

When the researchers reviewed routine mammograms performed in 71 women with ESRD, they found breast arterial calcifications in 63 percent of patients. In contrast, in a matched group of women without kidney disease, mammograms showed breast arterial calcifications in just 17 percent of cases.

Thirty-six percent of the women with kidney disease already had breast arterial calcifications on mammograms performed several years earlier -- before their kidney disease advanced to ESRD. More than 90 percent of women with calcifications of the breast artery also had evidence of medical calcifications in other blood vessels.

Calcium deposits seen on mammograms could be "a marker of generalized medical vascular calcifications" in patients with kidney disease, the researchers write. The results support the theory that CKD predisposes to medial calcification, which may in turn, contribute to cardiovascular disease.

Since most women with CKD are at an age where yearly mammograms are recommended, mammograms may be a useful tool for studying the development and progression of medical calcifications. O'Neill and colleagues call for further studies of arterial calcium deposits in patients with kidney disease -- including whether early identification and treatment might help to lower the associated risk of cardiovascular disease.

The study had some important limitations, including the relatively small number of patients studied.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Valerie Duhn, Ellen T. D'Orsi, Samuel Johnson, Carl J. D'Orsi, Amy L. Adams, W. Charles O'Neill. Breast Arterial Calcification: A Marker of Medial Vascular Calcification in Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology, 2011; DOI: 10.2215/CJN.07190810

Cite This Page:

American Society of Nephrology. "Mammograms: Detecting more than breast cancer, may help assess heart risk in kidney disease patients." ScienceDaily. ScienceDaily, 22 January 2011. <www.sciencedaily.com/releases/2011/01/110120171409.htm>.
American Society of Nephrology. (2011, January 22). Mammograms: Detecting more than breast cancer, may help assess heart risk in kidney disease patients. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2011/01/110120171409.htm
American Society of Nephrology. "Mammograms: Detecting more than breast cancer, may help assess heart risk in kidney disease patients." ScienceDaily. www.sciencedaily.com/releases/2011/01/110120171409.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins