Featured Research

from universities, journals, and other organizations

Useful biomarkers for esophageal squamous cell carcinoma

Date:
January 25, 2011
Source:
World Journal of Gastroenterology
Summary:
A research team from China investigated the expression profile of miRNA in esophageal squamous cell carcinoma (ESCC). They found that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC.

MicroRNAs (miRNAs) regulate gene expression by mainly binding to the 3′-UTR of target mRNAs, leading to mRNA degradation or translation inhibition. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China. Many studies have reported the miRNA expression profiles in Barrett's esophagus and esophageal adenocarcinoma. However, the pathobiological significance of aberrant miRNA expression in human ESCC has not been well documented.

Related Articles


A research article to be published on January 7, 2011 in the World Journal of Gastroenterology addresses this question. The authors reported the expression profile of miRNA in ESCC and investigated the expression and functions of miR-143 and miR-145 in ESCC.

The results showed that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC. Furthermore, rescued expression of miR-143 and miR-145 can inhibit cell mobility.

This study provides the first evidence for the anti-oncogenic activity of miR-143 and miR-145 in the development of esophageal squamous cell cancer. Targets of these two miRNAs remain to be defined. These results indicate that miRNAs may eventually constitute useful biomarkers as well as therapeutic targets.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wu BL, Xu LY, Du ZP, Liao LD, Zhang HF, Huang Q, Fang GQ, Li EM. MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145. World Journal of Gastroenterology, 2011; 17 (1): 79 DOI: 10.3748/wjg.v17.i1.79

Cite This Page:

World Journal of Gastroenterology. "Useful biomarkers for esophageal squamous cell carcinoma." ScienceDaily. ScienceDaily, 25 January 2011. <www.sciencedaily.com/releases/2011/01/110125103911.htm>.
World Journal of Gastroenterology. (2011, January 25). Useful biomarkers for esophageal squamous cell carcinoma. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2011/01/110125103911.htm
World Journal of Gastroenterology. "Useful biomarkers for esophageal squamous cell carcinoma." ScienceDaily. www.sciencedaily.com/releases/2011/01/110125103911.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins