Featured Research

from universities, journals, and other organizations

A mix of tiny gold and viral particles, and the DNA ties that bind them

Date:
January 28, 2011
Source:
University of Rochester Medical Center
Summary:
Scientists have created a diamond-like lattice composed of gold nanoparticles and viral particles, woven together and held in place by strands of DNA. The structure -- a distinctive mix of hard, metallic nanoparticles and organic viral pieces known as capsids, linked by the very stuff of life, DNA -- marks a remarkable step in scientists' ability to combine an assortment of materials to create infinitesimal devices.

Crystal lattice created by Sung Yong Park and colleagues.
Credit: Illustration by Adolf Lachman

Scientists have created a diamond-like lattice composed of gold nanoparticles and viral particles, woven together and held in place by strands of DNA. The structure -- a distinctive mix of hard, metallic nanoparticles and organic viral pieces known as capsids, linked by the very stuff of life, DNA -- marks a remarkable step in scientists' ability to combine an assortment of materials to create infinitesimal devices.

The research, done by scientists at the University of Rochester Medical Center, Scripps Research Institute, and Massachusetts Institute of Technology, was published recently in Nature Materials.

While people commonly think of DNA as a blueprint for life, the team used DNA instead as a tool to guide the precise positioning of tiny particles just one-millionth of a centimeter across, using DNA to chaperone the particles.

Central to the work is the unique attraction of each of DNA's four chemical bases to just one other base. The scientists created specific pieces of DNA and then attached them to gold nanoparticles and viral particles, choosing the sequences and positioning them exactly to force the particles to arrange themselves into a crystal lattice.

When scientists mixed the particles, out of the brew emerged a sodium thallium crystal lattice. The device "self assembled" or literally built itself.

The research adds some welcome flexibility to the toolkit that scientists have available to create nano-sized devices.

"Organic materials interact in ways very different from metal nanoparticles. The fact that we were able to make such different materials work together and be compatible in a single structure demonstrates some new opportunities for building nano-sized devices," said Sung Yong Park, Ph.D., a research assistant professor of Biostatistics and Computational Biology at Rochester.

Park and M.G Finn, Ph.D., of Scripps Research Institute are corresponding authors of the paper.

Such a crystal lattice is potentially a central ingredient to a device known as a photonic crystal, which can manipulate light very precisely, blocking certain colors or wavelengths of light while letting other colors pass. While 3-D photonic crystals exist that can bend light at longer wavelengths, such as the infrared, this lattice is capable of manipulating visible light. Scientists foresee many applications for such crystals, such as optical computing and telecommunications, but manufacturing and durability remain serious challenges.

It was three years ago that Park, as part of a larger team of colleagues at Northwestern University, first produced a crystal lattice with a similar method, using DNA to link gold nanospheres. The new work is the first to combine particles with such different properties -- hard gold nanoparticles and more flexible organic particles.

Within the new structure, there are actually two distinct forces at work, Park said. The gold particles and the viral particles repel each other, but their deterrence is countered by the attraction between the strategically placed complementary strands of DNA. Both phenomena play a role in creating the rigid crystal lattice. It's a little bit like how countering forces keep our curtains up: A spring in a curtain rod pushes the rod to lengthen, while brackets on the window frame counter that force, creating a taut, rigid device.

Other authors of the paper include Abigail Lytton-Jean, Ph.D., of MIT, Daniel Anderson, Ph.D., of Harvard and MIT, and Petr Cigler, Ph.D., formerly of Scripps Research Institute and now at the Academy of Sciences of the Czech Republic. Park's work was supported by the National Institute of Allergy and Infectious Diseases.


Story Source:

The above story is based on materials provided by University of Rochester Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Petr Cigler, Abigail K. R. Lytton-Jean, Daniel G. Anderson, M. G. Finn, Sung Yong Park. DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and proteinnanoparticles. Nature Materials, 2010; 9 (11): 918 DOI: 10.1038/nmat2877

Cite This Page:

University of Rochester Medical Center. "A mix of tiny gold and viral particles, and the DNA ties that bind them." ScienceDaily. ScienceDaily, 28 January 2011. <www.sciencedaily.com/releases/2011/01/110127131111.htm>.
University of Rochester Medical Center. (2011, January 28). A mix of tiny gold and viral particles, and the DNA ties that bind them. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/01/110127131111.htm
University of Rochester Medical Center. "A mix of tiny gold and viral particles, and the DNA ties that bind them." ScienceDaily. www.sciencedaily.com/releases/2011/01/110127131111.htm (accessed July 28, 2014).

Share This




More Matter & Energy News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Europe's Highest Train Turns 80 in French Pyrenees

Europe's Highest Train Turns 80 in French Pyrenees

AFP (July 25, 2014) Europe's highest train, the little train of Artouste in the French Pyrenees, celebrates its 80th birthday. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
TSA Administrator on Politics and Flight Bans

TSA Administrator on Politics and Flight Bans

AP (July 24, 2014) TSA administrator, John Pistole's took part in the Aspen Security Forum 2014, where he answered questions on lifting of the ban on flights into Israel's Tel Aviv airport and whether politics played a role in lifting the ban. (July 24) Video provided by AP
Powered by NewsLook.com
Creative Makeovers for Ugly Cellphone Towers

Creative Makeovers for Ugly Cellphone Towers

AP (July 24, 2014) Mobile phone companies and communities across the country are going to new lengths to disguise those unsightly cellphone towers. From a church bell tower to a flagpole, even a pencil, some towers are trying to make a point. (July 24) Video provided by AP
Powered by NewsLook.com
Algonquin Power Goes Activist on Its Target Gas Natural

Algonquin Power Goes Activist on Its Target Gas Natural

TheStreet (July 23, 2014) When The Deal's Amanda Levin exclusively reported that Gas Natural had been talking to potential suitors, the Ohio company responded with a flat denial, claiming its board had not talked to anyone about a possible sale. Lo and behold, Canadian utility Algonquin Power and Utilities not only had approached the company, but it did it three times. Its last offer was for $13 per share as Gas Natural's was trading at a 60-day moving average of about $12.50 per share. Now Algonquin, which has a 4.9% stake in Gas Natural, has taken its case to shareholders, calling on them to back its proposals or, possibly, a change in the target's board. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins