Featured Research

from universities, journals, and other organizations

Vitamin D deficiency alters lung growth and decreases lung function

Date:
January 28, 2011
Source:
American Thoracic Society
Summary:
Previously linked to the severity of asthma and chronic obstructive pulmonary disease in humans, vitamin D deficiency has now been shown to alter lung structure and function in young mice. The new study offers the first concrete evidence linking vitamin D deficiency with deficits in lung function and altered lung structure.

Previously linked to the severity of asthma and chronic obstructive pulmonary disease (COPD) in humans, vitamin D deficiency has now been shown to alter lung structure and function in young mice. The new study, conducted by researchers in Australia, offers the first concrete evidence linking vitamin D deficiency with deficits in lung function and altered lung structure.

The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"The results of this study clearly demonstrate that vitamin D deficiency alters lung growth, resulting in lower lung volume and decrements in lung function," said Graeme Zosky, PhD, a research fellow at the Telethon Institute for Child Health Research in Subiaco, Australia. "This is the first direct mechanistic evidence showing that vitamin D deficiency alters lung development, which may explain the association between obstructive lung disease and levels of vitamin D."

To conduct their study, the researchers used a mouse model of vitamin D deficiency and evaluated lung responses of two-week-old mice, comparing them to control mice without vitamin D deficiency to determine what, if any, effects the deficiency may have caused in the growth, structure or function of the lungs.

Lung volume and lung function were evaluated using a plethysmograph, an instrument used to measure the amount of air in the lung, and via forced oscillation, a technique used to measure the resistance to air flow in the lungs. Microscopic lung tissue samples were also evaluated to assess changes in lung structure.

"The aim of this study was to determine if vitamin D deficiency results in altered lung function and/or structure as a potential explanation for the association between vitamin D and chronic respiratory disease," said Dr. Zosky, who is also an adjunct senior lecturer at the University of Western Australia's Centre for Child Health Research. "Specifically, we aimed to determine if vitamin D deficiency has an influence on lung growth as indicated by a decrease in lung volume. We also wanted to determine if the deficiency alters the mechanical properties of the lung tissue due to changes in the structure of the lung."

The researchers found that airway resistance was significantly higher while lung volume was significantly lower in vitamin D-deficient mice compared to control mice. Examinations of specific tissue responses revealed model mice had reduced lung function. Lungs were also smaller in model mice, which Dr. Zosky said could have been caused by the deficiencies of the mother or of the offspring.

"Due to the nature of this study, we were not able to determine whether the differences in lung size and function we observed in the deficient offspring were the result of their own deficient status or as a consequence of developmental deficits that occurred in utero due to the mother's deficiency," he said.

Dr. Zosky noted that although recent studies suggest that vitamin D deficiency is associated with reduced lung function, causal data confirming a relationship between vitamin D and lung function have been lacking.

"For the first time, we have demonstrated a direct role for vitamin D in causing decreased lung function in the absence of known confounders such as physical inactivity, confirming the assertion by epidemiological studies that there is a relationship between vitamin D deficiency and lung function," Dr. Zosky said. "The differences we observed in lung volume and lung mechanics, which were substantial and physiologically relevant, raise serious concerns regarding the increased prevalence of vitamin D deficiency in communities around the world. The results also raise concerns about the potential this deficiency may have on lung health, and in particular, the potential impact deficiency may have on the susceptibility to obstructive lung disease."

Dr. Zosky said the study results have important implications for prevention of lung diseases in populations where vitamin D deficiencies are common. Future studies need to be conducted to determine whether vitamin D deficiency-induced alterations in lung growth increase the severity of obstructive lung disease and to identify susceptible populations whose use of dietary vitamin D supplementation could be used to improve lung health outcomes, he added.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. R. Zosky, L. J. Berry, J. G. Elliot, A. L. James, S. Gorman, P. H. Hart. Vitamin D Deficiency Causes Deficits in Lung Function and Alters Lung Structure. American Journal of Respiratory and Critical Care Medicine, 2011; DOI: 10.1164/rccm.201010-1596OC

Cite This Page:

American Thoracic Society. "Vitamin D deficiency alters lung growth and decreases lung function." ScienceDaily. ScienceDaily, 28 January 2011. <www.sciencedaily.com/releases/2011/01/110128121627.htm>.
American Thoracic Society. (2011, January 28). Vitamin D deficiency alters lung growth and decreases lung function. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/01/110128121627.htm
American Thoracic Society. "Vitamin D deficiency alters lung growth and decreases lung function." ScienceDaily. www.sciencedaily.com/releases/2011/01/110128121627.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins