Featured Research

from universities, journals, and other organizations

Key step in the development of a norovirus treatment

Date:
March 2, 2011
Source:
University of Southampton
Summary:
With the number of norovirus infection cases rising across the country, scientists have successfully crystallized a key norovirus enzyme, which could help in the development of a norovirus treatment.

This is a protein crystal of the Southampton norovirus protease bound to the inhibitor.
Credit: University of Southampton

With the number of norovirus infection cases rising across the country, scientists from the University of Southampton have successfully crystallised a key norovirus enzyme, which could help in the development of a norovirus treatment.

Related Articles


Noroviruses are recognised world-wide as the most important cause of epidemic nonbacterial gastroenteritis (stomach bugs) and pose a significant public health burden, with an estimated one million cases per year in the UK. In the past, noroviruses have also been called 'winter vomiting viruses'.

By crystallising the key protease enzyme, the research team from the University has been able to design an inhibitor that interacts with the enzyme from the 'Southampton' norovirus. The inhibitor works by preventing the enzyme in the norovirus from working, stopping the spread of infection.

The virus is called the Southampton virus because this particular virus was first found in an outbreak that came from a family in Southampton. Traditionally, individual noroviruses are named after the place from which the virus was first found, so for example the very first norovirus is known as Norwalk virus because it discovered in Norwalk in Ohio, America.

University of Southampton virologist Professor Ian Clarke says:

"Noroviruses place a huge burden on the NHS. This is an important step forward in the rational design of new drugs to treat norovirus infections. Now we know the drug works in the test tube, the next step is to see whether we can modify and deliver it to the site where the virus grows."

The research team hopes to translate their laboratory findings into an antiviral treatment for norovirus infection.

The work was performed by research student Rob Hussey in collaboration with University Professor Shoolingin-Jordan, the norovirus research group at Southampton General Hospital and Professor Jon Cooper at University College London. The project was part funded by the University of Southampton, the Hope Charity and the Wellcome Trust.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "Key step in the development of a norovirus treatment." ScienceDaily. ScienceDaily, 2 March 2011. <www.sciencedaily.com/releases/2011/02/110201084024.htm>.
University of Southampton. (2011, March 2). Key step in the development of a norovirus treatment. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2011/02/110201084024.htm
University of Southampton. "Key step in the development of a norovirus treatment." ScienceDaily. www.sciencedaily.com/releases/2011/02/110201084024.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins