Featured Research

from universities, journals, and other organizations

Key step in the development of a norovirus treatment

Date:
March 2, 2011
Source:
University of Southampton
Summary:
With the number of norovirus infection cases rising across the country, scientists have successfully crystallized a key norovirus enzyme, which could help in the development of a norovirus treatment.

This is a protein crystal of the Southampton norovirus protease bound to the inhibitor.
Credit: University of Southampton

With the number of norovirus infection cases rising across the country, scientists from the University of Southampton have successfully crystallised a key norovirus enzyme, which could help in the development of a norovirus treatment.

Related Articles


Noroviruses are recognised world-wide as the most important cause of epidemic nonbacterial gastroenteritis (stomach bugs) and pose a significant public health burden, with an estimated one million cases per year in the UK. In the past, noroviruses have also been called 'winter vomiting viruses'.

By crystallising the key protease enzyme, the research team from the University has been able to design an inhibitor that interacts with the enzyme from the 'Southampton' norovirus. The inhibitor works by preventing the enzyme in the norovirus from working, stopping the spread of infection.

The virus is called the Southampton virus because this particular virus was first found in an outbreak that came from a family in Southampton. Traditionally, individual noroviruses are named after the place from which the virus was first found, so for example the very first norovirus is known as Norwalk virus because it discovered in Norwalk in Ohio, America.

University of Southampton virologist Professor Ian Clarke says:

"Noroviruses place a huge burden on the NHS. This is an important step forward in the rational design of new drugs to treat norovirus infections. Now we know the drug works in the test tube, the next step is to see whether we can modify and deliver it to the site where the virus grows."

The research team hopes to translate their laboratory findings into an antiviral treatment for norovirus infection.

The work was performed by research student Rob Hussey in collaboration with University Professor Shoolingin-Jordan, the norovirus research group at Southampton General Hospital and Professor Jon Cooper at University College London. The project was part funded by the University of Southampton, the Hope Charity and the Wellcome Trust.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "Key step in the development of a norovirus treatment." ScienceDaily. ScienceDaily, 2 March 2011. <www.sciencedaily.com/releases/2011/02/110201084024.htm>.
University of Southampton. (2011, March 2). Key step in the development of a norovirus treatment. ScienceDaily. Retrieved April 17, 2015 from www.sciencedaily.com/releases/2011/02/110201084024.htm
University of Southampton. "Key step in the development of a norovirus treatment." ScienceDaily. www.sciencedaily.com/releases/2011/02/110201084024.htm (accessed April 17, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, April 17, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins