Featured Research

from universities, journals, and other organizations

Key step in the development of a norovirus treatment

Date:
March 2, 2011
Source:
University of Southampton
Summary:
With the number of norovirus infection cases rising across the country, scientists have successfully crystallized a key norovirus enzyme, which could help in the development of a norovirus treatment.

This is a protein crystal of the Southampton norovirus protease bound to the inhibitor.
Credit: University of Southampton

With the number of norovirus infection cases rising across the country, scientists from the University of Southampton have successfully crystallised a key norovirus enzyme, which could help in the development of a norovirus treatment.

Noroviruses are recognised world-wide as the most important cause of epidemic nonbacterial gastroenteritis (stomach bugs) and pose a significant public health burden, with an estimated one million cases per year in the UK. In the past, noroviruses have also been called 'winter vomiting viruses'.

By crystallising the key protease enzyme, the research team from the University has been able to design an inhibitor that interacts with the enzyme from the 'Southampton' norovirus. The inhibitor works by preventing the enzyme in the norovirus from working, stopping the spread of infection.

The virus is called the Southampton virus because this particular virus was first found in an outbreak that came from a family in Southampton. Traditionally, individual noroviruses are named after the place from which the virus was first found, so for example the very first norovirus is known as Norwalk virus because it discovered in Norwalk in Ohio, America.

University of Southampton virologist Professor Ian Clarke says:

"Noroviruses place a huge burden on the NHS. This is an important step forward in the rational design of new drugs to treat norovirus infections. Now we know the drug works in the test tube, the next step is to see whether we can modify and deliver it to the site where the virus grows."

The research team hopes to translate their laboratory findings into an antiviral treatment for norovirus infection.

The work was performed by research student Rob Hussey in collaboration with University Professor Shoolingin-Jordan, the norovirus research group at Southampton General Hospital and Professor Jon Cooper at University College London. The project was part funded by the University of Southampton, the Hope Charity and the Wellcome Trust.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "Key step in the development of a norovirus treatment." ScienceDaily. ScienceDaily, 2 March 2011. <www.sciencedaily.com/releases/2011/02/110201084024.htm>.
University of Southampton. (2011, March 2). Key step in the development of a norovirus treatment. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2011/02/110201084024.htm
University of Southampton. "Key step in the development of a norovirus treatment." ScienceDaily. www.sciencedaily.com/releases/2011/02/110201084024.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins