Featured Research

from universities, journals, and other organizations

How p53 is inactivated in cancerous cells, allowing tumors to grow

Date:
February 15, 2011
Source:
University of Alberta Faculty of Medicine & Dentistry
Summary:
One of the most important genes in the human genome is called p53 and its function is to suppress tumors, according to a team of researchers. They discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumors to grow.

One of the most important genes in the human genome is called p53 and its function is to suppress tumours, according to Roger Leng, a researcher in the Faculty of Medicine & Dentistry. Leng has discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumours to grow.

Related Articles


"Successful completion of the proposed experiments could lead to novel anti-cancer therapies that could potentially improve the prognosis for cancer patients and reduce the public health burden from cancer," said Leng.

It has long been known by scientists that another protein, MDM2, lowers p53 in the body, but in cancerous cells p53 is inactivated in more than 50 per cent of all human tumours. MDM2 does not have the ability to functionally silence the tumour suppressing protein on its own, leaving scientists wondering what molecule in the body is helping MDM2 to nearly eliminate p53 in cancerous cells.

Leng's lab has answered that question and the culprit is called UBE4B. Leng made the discovery because he found that UBE4B binds with both p53 and MDM2. From there his lab was able to discover the relationship between the proteins.

Paired with MDM2, also known as HDM2 in humans, the two proteins completely degrade p53 in a laboratory model. This is a process known as poly-ubiquitination, which means a specific protein completely disappears in a cell.

They also did experiments on cancerous human brain tissue and found the same results.

"They have the same function," said Leng. "The idea now is you can target UBE4B and MDM2 won't function."

This discovery was published online on the Nature Medicine website on Feb. 13.

Now, the Alberta Heritage Foundation for Medical Research Scholar and Canadian Institutes of Health Research funded scientist wants to further understand the mechanisms by which UBE4B functions.

"We want to understand how it regulates MDM2," said Leng. "We also want to see, if you get DNA damage, what happens in UBE4B and p53."

All of which could provide answers which eventually lead to a pharmacological target for cancer therapy.


Story Source:

The above story is based on materials provided by University of Alberta Faculty of Medicine & Dentistry. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hong Wu, Scott L Pomeroy, Manuel Ferreira, Natalia Teider, Juliana Mariani, Keiichi I Nakayama, Shigetsugu Hatakeyama, Victor A Tron, Linda F Saltibus, Leo Spyracopoulos, Roger P Leng. UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nature Medicine, 2011; DOI: 10.1038/nm.2283

Cite This Page:

University of Alberta Faculty of Medicine & Dentistry. "How p53 is inactivated in cancerous cells, allowing tumors to grow." ScienceDaily. ScienceDaily, 15 February 2011. <www.sciencedaily.com/releases/2011/02/110214092939.htm>.
University of Alberta Faculty of Medicine & Dentistry. (2011, February 15). How p53 is inactivated in cancerous cells, allowing tumors to grow. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2011/02/110214092939.htm
University of Alberta Faculty of Medicine & Dentistry. "How p53 is inactivated in cancerous cells, allowing tumors to grow." ScienceDaily. www.sciencedaily.com/releases/2011/02/110214092939.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins