Featured Research

from universities, journals, and other organizations

Blood glucose levels that predict 10-year risk of retinopathy identified

Date:
March 27, 2011
Source:
JAMA and Archives Journals
Summary:
Individuals who have higher blood glucose levels and poorer control of those levels over time appear more likely to develop eye-related complications 10 years later, according to a new article.

Individuals who have higher blood glucose levels and poorer control of those levels over time appear more likely to develop eye-related complications 10 years later, according to a report in the February issue of Archives of Ophthalmology.

Related Articles


The high blood glucose levels accompanying diabetes are known to be associated with microvascular complications, including the eye condition retinopathy, according to background information in the article. "However, some controversy concerns the actual value of this glycemic threshold for identifying retinopathy," the authors write. "It is now well established that the non-diabetic population also has retinopathy, albeit at a lower frequency than patients with diabetes and in a milder form, indicating that there may be factors other than fasting plasma glucose levels that increase the risk of retinopathy."

Pascale Massin, M.D., Ph.D., of Hôpital Lariboisière, Paris, and colleagues in the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study Group examined the retinas of 700 men and women (average age 52) who were enrolled in the study. Over the preceding nine years, their fasting plasma glucose levels and hemoglobin A1C (HbA1c, a measure of blood glucose control over time) had been tracked. In that time, 235 had diabetes (defined as being treated for the disease or having a glucose level of 126 milligrams per deciliter or higher at least once), 227 had an impaired fasting plasma glucose level (110 to 125 milligrams per deciliter) and 238 always had glucose levels within normal limits (less than 110 milligrams per deciliter).

Of the participants, 44 were classified as having retinopathy, including 19 with diabetes, 19 with impaired fasting glucose levels and six with normal glucose levels. Compared with those without retinopathy, those with the condition had higher average levels of fasting plasma glucose 10 years prior (130 vs. 106 milligrams per deciliter) and higher HbA1c (6.4 percent vs. 5.7 percent).

"Levels of HbA1c and fasting plasma glucose at baseline were related to the presence of retinopathy 10 years later, and the levels at which the positive predictive values increased provide a rationale for the choice of thresholds for the definition of hyperglycemia associated with 10-year retinopathy," the authors write. "We propose that thresholds of 108 milligrams per deciliter for fasting plasma glucose concentration and 6.0 percent for HbA1c level could be used to define those who are at risk of retinopathy; this is in agreement with our observation of a risk of retinopathy within the impaired fasting glucose range (fasting plasma glucose level, 110 milligrams per deciliter or higher)."

"Factors other than glucose measures play only a minor role in retinopathy," they conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Massin, C. Lange, J. Tichet, S. Vol, A. Erginay, M. Cailleau, E. Eschwege, B. Balkau. Hemoglobin A1c and Fasting Plasma Glucose Levels as Predictors of Retinopathy at 10 Years: The French DESIR Study. Archives of Ophthalmology, 2011; 129 (2): 188 DOI: 10.1001/archophthalmol.2010.353

Cite This Page:

JAMA and Archives Journals. "Blood glucose levels that predict 10-year risk of retinopathy identified." ScienceDaily. ScienceDaily, 27 March 2011. <www.sciencedaily.com/releases/2011/02/110214162937.htm>.
JAMA and Archives Journals. (2011, March 27). Blood glucose levels that predict 10-year risk of retinopathy identified. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/02/110214162937.htm
JAMA and Archives Journals. "Blood glucose levels that predict 10-year risk of retinopathy identified." ScienceDaily. www.sciencedaily.com/releases/2011/02/110214162937.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins