Featured Research

from universities, journals, and other organizations

Active wound healing can accelerate tumor formation, study finds

Date:
February 15, 2011
Source:
Karolinska Institutet
Summary:
Processes that are involved in active wound healing can lead to an increased risk for basal cell carcinoma in the skin, according to a new study.

Processes that are involved in active wound healing can lead to an increased risk for basal cell carcinoma in the skin.

This is the conclusion of a recent study from the Swedish medical university Karolinska Institutet, published in the Proceedings of the National Academy of Sciences.

The link between the development of basal cell cancers and wound healing was studied in mice with the same genetic changes that occur in human tumors. The results show that an active wound healing process can increase both the number and size of the tumours. The increase in tumour size is likely due to a general increase in cell proliferation taking place in association with wound healing whereas the increase in number is due to enhanced recruitment of cells with potential to initiate tumour formation.

Basal cell carcinoma (BCC) in the skin is the most common cancer and earlier case reports have described an increased risk of BCC associated with both chronic and acute wounds. This new study from Karolinska Institutet describes for the first time the underlying mechanism at the cellular level.

"We believe that exposure to UV radiation from the sun together with an active tissue regeneration process is a dangerous combination increasing the risk of developing basal cell carcinoma," says Rune Toftgεrd, Professor at Karolinska Institutet and principal author of the study.

He points out that there is epidemiological evidence strongly supporting the hypothesis that severe sunburn -- severe enough to cause tissue damage -- is an important risk factor for development of BCC.

In the current study 'lineage tracing' was used to determine where and in which cells tumour formation started. Lineage tracing is a technique to label a cell permanently making it possible to follow this cell and all of its daughter cells. In this way it was found that stem cells of the hair follicle actively contribute to wound healing and that such stem cells and/ or their daughter cells migrate out of the hair follicle to promote wound repair.

As a result of the wound healing process, hair follicle stem cells and their daughter cells present in the non-follicular part of the skin (interfollicular epidermis) acquire the ability to initiate tumour formation also in their new location. Moreover, the study shows that not all types of wounds are sufficient to increase tumour formation. Damage to the deeper parts of the skin (so-called full-thickness wounding) is required to elicit the tumour enhancing effect.

"One may assume that the combination of tissue damage from severe sunburn, and DNA damage or mutations caused by UV radiation has a similar effect," says Rune Toftgεrd.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Kasper, V. Jaks, A. Are, A. Bergstrom, A. Schwager, N. Barker, R. Toftgard. Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1014489108

Cite This Page:

Karolinska Institutet. "Active wound healing can accelerate tumor formation, study finds." ScienceDaily. ScienceDaily, 15 February 2011. <www.sciencedaily.com/releases/2011/02/110215081918.htm>.
Karolinska Institutet. (2011, February 15). Active wound healing can accelerate tumor formation, study finds. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/02/110215081918.htm
Karolinska Institutet. "Active wound healing can accelerate tumor formation, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/02/110215081918.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins