Featured Research

from universities, journals, and other organizations

Active wound healing can accelerate tumor formation, study finds

Date:
February 15, 2011
Source:
Karolinska Institutet
Summary:
Processes that are involved in active wound healing can lead to an increased risk for basal cell carcinoma in the skin, according to a new study.

Processes that are involved in active wound healing can lead to an increased risk for basal cell carcinoma in the skin.

This is the conclusion of a recent study from the Swedish medical university Karolinska Institutet, published in the Proceedings of the National Academy of Sciences.

The link between the development of basal cell cancers and wound healing was studied in mice with the same genetic changes that occur in human tumors. The results show that an active wound healing process can increase both the number and size of the tumours. The increase in tumour size is likely due to a general increase in cell proliferation taking place in association with wound healing whereas the increase in number is due to enhanced recruitment of cells with potential to initiate tumour formation.

Basal cell carcinoma (BCC) in the skin is the most common cancer and earlier case reports have described an increased risk of BCC associated with both chronic and acute wounds. This new study from Karolinska Institutet describes for the first time the underlying mechanism at the cellular level.

"We believe that exposure to UV radiation from the sun together with an active tissue regeneration process is a dangerous combination increasing the risk of developing basal cell carcinoma," says Rune Toftgεrd, Professor at Karolinska Institutet and principal author of the study.

He points out that there is epidemiological evidence strongly supporting the hypothesis that severe sunburn -- severe enough to cause tissue damage -- is an important risk factor for development of BCC.

In the current study 'lineage tracing' was used to determine where and in which cells tumour formation started. Lineage tracing is a technique to label a cell permanently making it possible to follow this cell and all of its daughter cells. In this way it was found that stem cells of the hair follicle actively contribute to wound healing and that such stem cells and/ or their daughter cells migrate out of the hair follicle to promote wound repair.

As a result of the wound healing process, hair follicle stem cells and their daughter cells present in the non-follicular part of the skin (interfollicular epidermis) acquire the ability to initiate tumour formation also in their new location. Moreover, the study shows that not all types of wounds are sufficient to increase tumour formation. Damage to the deeper parts of the skin (so-called full-thickness wounding) is required to elicit the tumour enhancing effect.

"One may assume that the combination of tissue damage from severe sunburn, and DNA damage or mutations caused by UV radiation has a similar effect," says Rune Toftgεrd.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Kasper, V. Jaks, A. Are, A. Bergstrom, A. Schwager, N. Barker, R. Toftgard. Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1014489108

Cite This Page:

Karolinska Institutet. "Active wound healing can accelerate tumor formation, study finds." ScienceDaily. ScienceDaily, 15 February 2011. <www.sciencedaily.com/releases/2011/02/110215081918.htm>.
Karolinska Institutet. (2011, February 15). Active wound healing can accelerate tumor formation, study finds. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/02/110215081918.htm
Karolinska Institutet. "Active wound healing can accelerate tumor formation, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/02/110215081918.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins