Featured Research

from universities, journals, and other organizations

Nanoparticles increase survival after blood loss, study suggests

Date:
February 22, 2011
Source:
Albert Einstein College of Medicine
Summary:
In an advance that could improve battlefield and trauma care, scientists have used tiny particles called nanoparticles to improve survival after life-threatening blood loss. Nanoparticles containing nitric oxide were infused into the bloodstream of hamsters, where they helped maintain blood circulation and protect vital organs.

In an advance that could improve battlefield and trauma care, scientists at Albert Einstein College of Medicine of Yeshiva University have used tiny particles called nanoparticles to improve survival after life-threatening blood loss. Nanoparticles containing nitric oxide (NO) were infused into the bloodstream of hamsters, where they helped maintain blood circulation and protect vital organs. The research was reported in the February 21 online edition of the journal Resuscitation.

"The new nanomedicine was developed to address the need for better field treatments for massive human blood loss, which can cause cardiovascular collapse, also known as hemorrhagic shock. This potentially fatal condition is best treated with infusions of refrigerated blood and other fluids. But such treatments are limited to emergency rooms or trauma centers.

"It is highly impractical to pack these supplies for use in rural emergencies, mass-casualty disasters or on the battlefield," said coauthor Joel Friedman, M.D., Ph.D., professor of physiology & medicine and of medicine and the Young Men's Division Chair in Physiology at Einstein. "Our nanoparticle therapy may offer the potential for saving lives in those situations. It's lightweight and compact and doesn't require refrigeration."

The new therapy counters hemorrhagic shock by increasing the body's levels of NO gas, which, among other physiological functions, relaxes blood vessels and regulates blood pressure. The gas was encased in microscopic-sized particles that were specially designed by the Einstein team. (NO is so short-lived that delivering it in therapeutic amounts requires a method of sustained release.) The therapy is created by adding the NO-containing nanoparticles to saline solution, which was then infused into the animals. Once in the body, the nanoparticles gradually release a sustained dose of NO to tissues.

The nanomedicine was successfully tested in hamsters that had lost half their blood volume. "Animals given the nanoparticles exhibited better cardiac stability, stronger blood flow to tissues and other measures of hemorrhagic shock recovery compared to controls receiving saline solution minus the nanoparticles," reported Dr. Friedman.

Previously published studies by Dr. Friedman and colleagues have demonstrated the beneficial effects of NO-containing nanoparticles for healing antibiotic-resistant staph infections and abscess caused by those bacteria and for treating erectile dysfunction.


Story Source:

The above story is based on materials provided by Albert Einstein College of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Parimala Nachuraju, Adam J. Friedman, Joel M. Friedman, Pedro Cabrales. Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock★. Resuscitation, 2011; DOI: 10.1016/j.resuscitation.2010.12.025

Cite This Page:

Albert Einstein College of Medicine. "Nanoparticles increase survival after blood loss, study suggests." ScienceDaily. ScienceDaily, 22 February 2011. <www.sciencedaily.com/releases/2011/02/110222151346.htm>.
Albert Einstein College of Medicine. (2011, February 22). Nanoparticles increase survival after blood loss, study suggests. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/02/110222151346.htm
Albert Einstein College of Medicine. "Nanoparticles increase survival after blood loss, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/02/110222151346.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins