Featured Research

from universities, journals, and other organizations

Lymph node dissection is not essential in small screen-detected lung cancers, new research shows

Date:
March 1, 2011
Source:
International Association for the Study of Lung Cancer
Summary:
Lymph node dissection, the current standard surgical treatment for localized non-small cell lung cancers, may be unnecessary in certain screen-detected early stage cases.

Lymph node dissection, the current standard surgical treatment for localized non-small cell lung cancers, may be unnecessary in certain screen-detected early stage cases , according to a study published in the March issue of the Journal of Thoracic Oncology (JTO), the official journal of the International Association for the Study of Lung Cancer.

Related Articles


The risk of nodal involvement is very low in early-stage cancers with a maximum standard uptake value (maxSUV) of 2.0 or a nodule smaller than 10 millimeters, researchers found.

"As a consequence of advances in diagnostic imaging, such as high-resolution or spiral computed tomography, thoracic surgeons encounter more often than in the past small-sized lung cancers at an earlier and potentially curable stage," said lead researcher Dr. Giulia Veronesi, MD, director of the Lung Cancer Early Detection Unit in the Division of Thoracic Surgery at the European Institute of Oncology in Milan, Italy. "It has thus become increasingly crucial to choose the most advantageous treatment strategy, including surgical intervention."

A total of 5,201 asymptomatic volunteers were recruited for the Continuing Observation of Smoking Subjects (COSMOS) trial in 2004 and 2005. All were 50 years or older, heavy smokers (20 pack years) or former heavy smokers who had quit within the previous 10 years.

Over the course of the next five years, lung cancer was detected by screening in 97 patients who also satisfied the criteria for the study. The tumors in 91 of those patients (94%) were N0 and in six (6.2%) were N+. All patients with tumors smaller than 10 mm or with a maximum SUV of less than 2.0 (62 cases) were N0. Nodal metastases occurred only among the 29 patients (17%) with lung nodules greater than 10 mm and maxSUV of 2.0 or more.

"These two simple variables were reliable predictors of lymph node involvement in early stage lung cancer, and will make it possible to avoid nodal dissection in a considerable number of patients, reducing operating time and invasiveness, and also reducing the morbidity associated with nodal dissection such as recurrent nerve injury and chylothorax," Veronesi said. "By contrast, when both variables were above the cutoffs identified in this study, radical lymph node dissection the risk of occult nodal involvement was fairly high, suggesting a radical lymph node dissection.

"These results imply for the future not only the reduction of cases requiring lymph node dissection but will allow us to propose safely lung-sparing sublobar resections instead of lobectomy in many patients with very initial lung cancer," she said.


Story Source:

The above story is based on materials provided by International Association for the Study of Lung Cancer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Giulia Veronesi, Patrick Maisonneuve, Giuseppe Pelosi, Monica Casiraghi, Bernardo G. Agoglia, Alessandro Borri, Laura L. Travaini, Massimo Bellomi, Cristiano Rampinelli, Daniela Brambilla, Raffaella Bertolotti, Lorenzo Spaggiari. Screening-Detected Lung Cancers. Journal of Thoracic Oncology, 2011; 6 (3): 525 DOI: 10.1097/JTO.0b013e318206dbcc

Cite This Page:

International Association for the Study of Lung Cancer. "Lymph node dissection is not essential in small screen-detected lung cancers, new research shows." ScienceDaily. ScienceDaily, 1 March 2011. <www.sciencedaily.com/releases/2011/03/110301091117.htm>.
International Association for the Study of Lung Cancer. (2011, March 1). Lymph node dissection is not essential in small screen-detected lung cancers, new research shows. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/03/110301091117.htm
International Association for the Study of Lung Cancer. "Lymph node dissection is not essential in small screen-detected lung cancers, new research shows." ScienceDaily. www.sciencedaily.com/releases/2011/03/110301091117.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins