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Geneticists unveil workings of three genes that control cell development and growth

Date:
March 1, 2011
Source:
University of Montreal
Summary:
By working with Canadians of French ancestry who suffer a rare genetic disease, researchers have discovered how three genes contribute to abnormal growth, making a breakthrough that will improve our understanding of many disorders such as fetal and childhood growth retardation, abnormal development of body parts and cancer.

By working with Canadians of French ancestry who suffer a rare genetic disease, researchers have discovered how three genes contribute to abnormal growth, making a breakthrough that will improve our understanding of many disorders such as fetal and childhood growth retardation, abnormal development of body parts and cancer.

"As a result of the Human Genome Project, we know the basic identity of essentially all the genes in the human body, but we don't automatically know what they do in detail," explained lead researcher Dr. Mark Samuels of the University of Montreal's Department of Medicine and the Sainte-Justine University Hospital Research Centre. "It's like opening your car and seeing the parts, but not knowing what each one does. When a part breaks however, you learn how it fits with the rest of the machine. Working with people who have specific health or development problems linked to specific genes enables us to see how those genes contribute to our bodies' development and functioning."

In this case, the team of researchers characterized the molecular basis in patients who suffer from Meier-Gorlin Syndrome (MGS), a rare disorder that is characterized by short stature, small ears, and absent or underdeveloped knee-caps. The patients were mostly francophonic, coming from the Maritimes, Quebec, British Columbia as well as the Louisiana Cajun community. MGS is a classic "single gene disorder," meaning it is related to mutations in individual genes, although in the case of MGS different patients surprisingly seem to carry mutations in any of three different genes.

The genes are called ORC1L, ORC4L and CDT1, and are known to play a critical role in correct copying of DNA. Cells reproduce by dividing in two. All the chromosomes must also be duplicated. This process is tightly controlled to prevent having too many or two few copies of large segments of the genome. "This seems to be the first example of any naturally occurring, inherited mutations identified in this set of important regulatory genes in any mammal. Finding the genes is a great example of the value of this type of research," Samuels said. "We learn the cause of the disease, and discover new things about our cellular function. However we still have a lot to learn about why mutations in these genes lead to the specific consequences in Meier-Gorlin patients."

There are 20-25,000 genes in the human genetic sequence, and it's important to note that they don't necessarily each correspond to a specific function or group of functions, or indeed to a single disease. The same gene can have subtle effects on a number of bodily functions. Moreover, in complex genetic diseases -- diabetes, for example -- environment and lifestyle have as much or more of an impact on health than a person's genetic background.

"Understanding rare genetic conditions like MGS is important to the general public for two reasons," Samuels stressed. "Firstly, they provide insight into how our genes, and therefore our bodies, work. Secondly, although there are few people concerned for each particular disorder, in sum all patients with genetic conditions consume substantial amounts of health resources, and by diagnosing them more quickly, we can improve patient management and reduce the strain on the health care system." Research suggests that up to 70% of admissions to paediatric hospitals may be related to some kind of genetic disorder. "It's also important to note that behind the science and the statistics, there are real people suffering. It's an immense relief for patients and their families to finally have a clear diagnosis," Samuels added.

In an unusual coincidence, a competing team of researchers obtained similar findings on Meier-Gorlin Syndrome in a different set of patients. These findings were published in the same issue of Nature Genetics. Samuels notes, "Neither team can claim absolute priority in the discovery. However this is the way science works best: when important results are quickly verified by multiple teams independently."

The findings were published in Nature Genetics and involved researchers from Dalhousie University, the University of Montreal-CHU Ste-Justine, the University of Louisiana and the University of British Columbia. The AMGGI project is funded by Industry Canada via Genome Canada and Genome Atlantic, as well as a large number of organizations, including the Atlantic Canada Opportunities Agency -- Atlantic Innovation Fund, Dalhousie University, Capital Health and the IWK Foundation.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Duane L Guernsey, Makoto Matsuoka, Haiyan Jiang, Susan Evans, Christine Macgillivray, Mathew Nightingale, Scott Perry, Meghan Ferguson, Marissa LeBlanc, Jean Paquette, Lysanne Patry, Andrea L Rideout, Aidan Thomas, Andrew Orr, Chris R McMaster, Jacques L Michaud, Cheri Deal, Sylvie Langlois, Duane W Superneau, Sandhya Parkash, Mark Ludman, David L Skidmore, Mark E Samuels. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Nature Genetics, 2011; DOI: 10.1038/ng.777

Cite This Page:

University of Montreal. "Geneticists unveil workings of three genes that control cell development and growth." ScienceDaily. ScienceDaily, 1 March 2011. <www.sciencedaily.com/releases/2011/03/110301091221.htm>.
University of Montreal. (2011, March 1). Geneticists unveil workings of three genes that control cell development and growth. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/03/110301091221.htm
University of Montreal. "Geneticists unveil workings of three genes that control cell development and growth." ScienceDaily. www.sciencedaily.com/releases/2011/03/110301091221.htm (accessed April 24, 2014).

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