Featured Research

from universities, journals, and other organizations

Possible role of damaged DNA in tumor development

Date:
March 6, 2011
Source:
Emory University
Summary:
DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

Paul Doetsch, PhD, professor of radiation oncology and biochemistry and associate director for basic research at Emory's Winship Cancer Institute and Damien Brégeon, PhD, at Institut de Génétique et Microbiologie in Paris, have outlined the role this process -- known as transcriptional mutagenesis -- might play in tumor development in a Nature Reviews Cancer article published online February 24th and in the March 2011 print edition.

"The majority of human cells do not multiply continuously but are slow-replicating and devote a large part of their energy to transcription," say the authors. "DNA damage can miscode at the damaged site and produce mutant transcripts. This process is transcriptional mutagenesis and could lead to the production of mutant proteins and may therefore be important in tumor development."

Transcriptional mutagenesis occurs when cells with damaged DNA produce bad messages during transcription, which leads to the creation of mutant proteins. Scientists already have learned that some genetic damages may block the transcription process, which is a signal for DNA repair molecules to move in and correct the mistake. When certain types of DNA damage are present, however, the non-dividing cells are capable of continuing transcription through the damage despite the erroneous coding messages. This problem can be exacerbated when cells have defects for repairing DNA damage.

As Doetsch and Brégeon note, data on this process are accumulating in several laboratories around the world, and evidence is mounting that transcriptional mutagenesis could have an important role in tumor develop­ment and other biological outcomes, including the development of drug resistance. However, at this point there is not enough evidence to know the extent to which transcriptional mutagenesis is involved in tumor development.

"One will have to fol­low the progeny of a single cell to determine whether cancerous growth can be initiated by the transient expression of oncogenic pro­teins or the disruption of signaling pathways," the authors say. "Future studies addressing these issues will provide additional insights into the mechanisms and consequences of transcriptional mutagenesis and further establish the role of this process in tumor development."


Story Source:

The above story is based on materials provided by Emory University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Damien Brégeon, Paul W. Doetsch. Transcriptional mutagenesis: causes and involvement in tumour development. Nature Reviews Cancer, 2011; 11 (3): 218 DOI: 10.1038/nrc3006

Cite This Page:

Emory University. "Possible role of damaged DNA in tumor development." ScienceDaily. ScienceDaily, 6 March 2011. <www.sciencedaily.com/releases/2011/03/110304115400.htm>.
Emory University. (2011, March 6). Possible role of damaged DNA in tumor development. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2011/03/110304115400.htm
Emory University. "Possible role of damaged DNA in tumor development." ScienceDaily. www.sciencedaily.com/releases/2011/03/110304115400.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins