Featured Research

from universities, journals, and other organizations

Two proteins play key roles in Burkitt's lymphoma

Date:
March 7, 2011
Source:
Sbarro Health Research Organization
Summary:
A new study reveals new molecular insight into the understanding and treatment of Burkitt`s lymphoma, one of the most aggressive tumors affecting humans.

Burkitt's lymphoma is one of the most aggressive tumors affecting humans. Multiple alterations in genes that regulate cell proliferation rate explain its aggressive behavior.

A new study reveals new molecular insight into the understanding and treatment of Burkitt`s lymphoma. The new finding concentrates on a genetic locus -- a piece of DNA with one or more genes which is the specific location of a gene or DNA sequence on a chromosome -- called INK4a/ARF locus. This locus encodes two important tumor suppressor genes, p16 and p14, and is usually inactivated in human tumors by genetic mutations. By controlling p53 and Rb pathways, p14(ARF) and p16(INK4a) inactivation allow the cells to overcome anti-oncogenic barriers and proliferate in an uncontrolled manner. Researchers found that in Burkitt`s lymphoma, the locus is genetically unchanged but the product proteins are inactivated by epigenetic and posttranscriptional mechanisms.

The research was done by the Sbarro Health Research Organization Center for Biotechnology, a nonprofit research center for cancer, cardiovascular and diabetes research, located in the College of Science and Technology at Temple University in Philadelphia, PA, and the University of Siena in Siena, Italy and published in Cell Cycle.

"We discovered a completely new mechanism for INK4/ARF protein inactivation," said Annalisa Roberti, lead author of the paper. "Since in Burkitt`s lymphoma these two proteins are not inactivated at the genetic level, their inactivation could be pharmacologically reversible. The reactivation of p16 and p14 in our model and our ability to inhibit cell proliferation and induce apoptosis through the Rb- and p-53 pathways opens new prospects for the understanding and treatment of Burkitt's lymphoma."

"This is an additional piece of the complex puzzle in which the Rb family, which includes Rb2/p130, plays an important role. The new discovery in our laboratory presents additional evidence that more and more, Rb is becoming to be viewed as a guardian of our genome," notes Antonio Giordano, M.D., Ph.D., Founder of SHRO and Director of the Sbarro Institute for Cancer Research and Molecular Medicine.


Story Source:

The above story is based on materials provided by Sbarro Health Research Organization. Note: Materials may be edited for content and length.


Journal Reference:

  1. Annalisa Roberti, Flavio Rizzolio, Chiara Lucchetti, Laurence de Leval, Antonio Giordano. Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt`s lymphoma cell lines. Cell Cycle, 2011; 10 (1): 127 DOI: 10.4161/cc.10.1.14446

Cite This Page:

Sbarro Health Research Organization. "Two proteins play key roles in Burkitt's lymphoma." ScienceDaily. ScienceDaily, 7 March 2011. <www.sciencedaily.com/releases/2011/03/110307093027.htm>.
Sbarro Health Research Organization. (2011, March 7). Two proteins play key roles in Burkitt's lymphoma. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/03/110307093027.htm
Sbarro Health Research Organization. "Two proteins play key roles in Burkitt's lymphoma." ScienceDaily. www.sciencedaily.com/releases/2011/03/110307093027.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins