Featured Research

from universities, journals, and other organizations

Research could lead to new prostate cancer drugs

Date:
March 17, 2011
Source:
Association for International Cancer Research
Summary:
New research could lead to new drugs for prostate cancer. Scientists will investigate the mechanism that controls alterations in cells in the prostate gland and the possibility that prostate cancer arises because of some form of mistaken change happening to these cells.

Research by scientists in America, funded by an international charity based in Scotland, could lead to new drugs for prostate cancer.

Dr Cynthia K Miranti will investigate the mechanism that controls alterations in cells in the prostate gland and the possibility that prostate cancer arises because of some form of mistaken change happening to these cells.

This sort of 'mistaken change' has been found to be the cause of at least one type of leukemia, which can now be treated with drugs to force the cells to complete the proper change.

If Dr Miranti and her team at the Van Andel Research Institute, in Grand Rapids, Michigan, find that theory to be correct, it could lead to new drugs to fight prostate cancer being designed.

The prostate gland is composed of two layers, the lower comprises the smaller basal cells and the upper layer the larger, secretory cells.

Dr Miranti recently discovered that a hormone-like molecule called KGF could make the basal cells develop into secretory cells, suggesting that, in the healthy prostate gland, as the secretory cells wear out and die, they are replaced by cells from the basal layer undergoing this change. This discovery also suggests a possible new explanation for how prostate cancer arises.

Prostate cancer cells have some of the characteristics of basal cells and some of the characteristics of secretory cells. Should the process of changing from one cell type to another go wrong, it could create an early form of a prostate cancer cell.

Said Dr Miranti: "It is not a simple switch, multiple steps are involved when basal cells change into secretory cells.

"We are investigating which specific molecules are responsible for this change in the normal, healthy gland and trying to map the order of the events involved. At the same time, we are determining where within this sequence of events things start to go wrong to cause prostate cancer. We are doing this by looking at genes that are known to be involved in prostate cancer and examining how these genes interfere with the ability of the cells to complete the change. Very little is known about how prostate cancer initially arises and our studies will help answer that question.

"It is currently difficult to determine whether a patient's tumour will grow slowly and not harm the patient, or whether it will be more aggressive and spread around their body. One possible outcome of our studies is that we could use our findings to design treatments that "push" the tumour cells to complete the change into secretory cells, similar to what is done in some leukemia. This would greatly reduce the aggressiveness of the cancer and reduce the risk of cancer spread and ultimately, death."

Dr Mark Matfield, AICR's scientific co-ordinator said: "The more we understand about the basic mechanisms of all the different cancers, the more likely we are to find potential new ways to treat it. This is exactly what Dr Miranti has done with her important discoveries about basal and secretory cells in the prostate."

Funding is provided by a 179,532 grant from the Association for International Cancer Research (AICR).


Story Source:

The above story is based on materials provided by Association for International Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

Association for International Cancer Research. "Research could lead to new prostate cancer drugs." ScienceDaily. ScienceDaily, 17 March 2011. <www.sciencedaily.com/releases/2011/03/110317093358.htm>.
Association for International Cancer Research. (2011, March 17). Research could lead to new prostate cancer drugs. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/03/110317093358.htm
Association for International Cancer Research. "Research could lead to new prostate cancer drugs." ScienceDaily. www.sciencedaily.com/releases/2011/03/110317093358.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins