Featured Research

from universities, journals, and other organizations

New study adds weight to diabetes drug link to heart problems

Date:
March 18, 2011
Source:
BMJ-British Medical Journal
Summary:
A new study adds to mounting evidence that rosiglitazone -- a drug used to treat Type 2 diabetes -- is associated with an increased risk of major heart problems.

A new study published on the British Medical Journal website adds to mounting evidence that rosiglitazone -- a drug used to treat type 2 diabetes -- is associated with an increased risk of major heart problems.

It finds that rosiglitazone is associated with significantly higher odds of congestive heart failure, heart attack and death compared with a similar drug (pioglitazone).

Rosiglitazone and pioglitazone belong to a class of drugs called thiazolidinediones that help to control blood sugar levels in patients with type 2 diabetes. Both drugs are known to increase the risk of heart failure, but it is unclear whether there are clinically important differences in their cardiac safety.

In 2010, the European Medicines Agency suspended the use of rosiglitazone in Europe, but in the United States it is still available on a restricted basis.

So a team of researchers in the UK and the US set out to compare the cardiovascular effects of the two drugs among patients with type 2 diabetes.

They analysed the results of 16 studies involving 810,000 patients (429,000 on rosiglitazone and 381,000 on pioglitazone). Most patients were aged over 60 years.

Compared with pioglitazone, rosiglitazone was associated with a modest but statistically significant increased risk of heart attack (16%), congestive heart failure (23%), and mortality (14%).

In certain groups of patients with type 2 diabetes, this may lead to 170 excess heart attacks, 649 excess cases of heart failure, and 431 excess deaths for every 100,000 patients who receive rosiglitazone rather than pioglitazone.

Further adjusting the data to minimise bias, did not change the results significantly, suggesting that this is unlikely to be a chance finding, say the authors.

"Our findings have important implications," they write. "Rosiglitazone is still available on a restricted basis in the United States and Canada. However, for patients who need thiazolidinedione treatment, continued use of rosiglitazone may lead to excess heart attacks, heart failure and mortality, compared with pioglitazone."

Given that there are about 3.8 million prescriptions for rosiglitazone dispensed annually in the United States, "the effect on public health may be considerable," they warn.

They also emphasise that both rosiglitazone and pioglitazone have been linked with other important safety concerns, and say that further studies are needed.

In an accompanying editorial, Victor Montori and Nilay Shah from the Mayo Clinic in the US argue that the rosiglitazone story "says much about how healthcare has become less about promoting patients' interests, alleviating illness, promoting function and independence, and curing disease, and much more about promoting other interests, including those of the drug industry."

They believe that regulators, prescribers, and patients all have a role in promoting patient safety and they urge patients to become engaged in decisions about their diabetes treatment.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. K. Loke, C. S. Kwok, S. Singh. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ, 2011; 342 (mar17 1): d1309 DOI: 10.1136/bmj.d1309

Cite This Page:

BMJ-British Medical Journal. "New study adds weight to diabetes drug link to heart problems." ScienceDaily. ScienceDaily, 18 March 2011. <www.sciencedaily.com/releases/2011/03/110317210317.htm>.
BMJ-British Medical Journal. (2011, March 18). New study adds weight to diabetes drug link to heart problems. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/03/110317210317.htm
BMJ-British Medical Journal. "New study adds weight to diabetes drug link to heart problems." ScienceDaily. www.sciencedaily.com/releases/2011/03/110317210317.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins