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Streptococcus enzyme could compete with toothbrushes, dental floss

Date:
March 22, 2011
Source:
American Society for Microbiology
Summary:
Investigators from Japan show in vitro that the bacterium Streptococcus salivarius, a non-biofilm forming, and otherwise harmless inhabitant of the human mouth, actually inhibits the formation of dental biofilms, otherwise known as plaque. Two enzymes this bacteria produces are responsible for this inhibition.

Investigators from Japan show in vitro that the bacterium Streptococcus salivarius, a non-biofilm forming, and otherwise harmless inhabitant of the human mouth, actually inhibits the formation of dental biofilms, otherwise known as plaque. Two enzymes this bacteria produces are responsible for this inhibition.

The research is published in the March 2011 issue of the journal Applied and Environmental Microbiology.

"FruA may be useful for prevention of dental caries," corresponding author Hidenobu Senpuku, of the National Institute of Infectious Diseases, Tokyo says of one of the enzymes. "The activity of the inhibitors was elevated in the presence of sucrose, and the inhibitory effects were dependent on the sucrose concentration in the biofilm formation assay medium," the researchers write.

"We show that FruA produced by S. salivarius inhibited S. mutans biofilm formation completely in the in vitro assay supplemented with sucrose," the researchers write. S. salivarius is the primary species of bacteria inhabiting the mouth, according to the report.

The authors suggest that FruA may actually regulate microbial pathogenicity in the oral cavity. They found that a commercial FruA, produced by Aspergillus niger, was as effective as S. salivarius FruA at inhibiting S. mutans biofilm formation, despite the fact that its amino acid composition is somewhat different from that of S. salivarius.

FruA is produced not only by S. salivarius, but by other oral streptococci. Much of the oral microbial flora consists of many beneficial species of bacteria that help maintain oral health and control the progression of oral disease.

(A. Ogawa, S. Furukawa, S. Fujita, J. Mitobe, T. Kawarai, N. Narisawa, T. Sekizuka, M. Kuroda, K. Ochiai, H. Ogihara, S. Kosono, S. Yoneda, H. Watanabe, Y. Morinaga, H. Uematsu, and H. Senpuku, 2011. Inhibition of Streptococcus mutans biofilm formation by Streptococcus salivarius FruA. Appl. Environ. Microbiol. 77:1572-1580.)


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Ogawa, S. Furukawa, S. Fujita, J. Mitobe, T. Kawarai, N. Narisawa, T. Sekizuka, M. Kuroda, K. Ochiai, H. Ogihara, S. Kosono, S. Yoneda, H. Watanabe, Y. Morinaga, H. Uematsu, H. Senpuku. Inhibition of Streptococcus mutans Biofilm Formation by Streptococcus salivarius FruA. Applied and Environmental Microbiology, 2011; 77 (5): 1572 DOI: 10.1128/AEM.02066-10

Cite This Page:

American Society for Microbiology. "Streptococcus enzyme could compete with toothbrushes, dental floss." ScienceDaily. ScienceDaily, 22 March 2011. <www.sciencedaily.com/releases/2011/03/110321203139.htm>.
American Society for Microbiology. (2011, March 22). Streptococcus enzyme could compete with toothbrushes, dental floss. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2011/03/110321203139.htm
American Society for Microbiology. "Streptococcus enzyme could compete with toothbrushes, dental floss." ScienceDaily. www.sciencedaily.com/releases/2011/03/110321203139.htm (accessed April 21, 2014).

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