Featured Research

from universities, journals, and other organizations

Smoking in combination with immunosuppression poses greater risk for transplant-related carcinoma

Date:
March 29, 2011
Source:
Wiley-Blackwell
Summary:
Researchers have found that liver transplant recipients who quit smoking have a lower incidence of smoking-related malignancies (SRM) than patients who keep smoking. In fact, SRMs were identified in 13.5 percent of deceased patients and smoking was associated with a higher risk of malignancy in this study.

Spanish researchers have found that liver transplant recipients who quit smoking have a lower incidence of smoking-related malignancies (SRM) than patients who keep smoking. In fact, SRMs were identified in 13.5% of deceased patients and smoking was associated with a higher risk of malignancy in this study. Full findings are published in the April issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases.

While smoking is a well-known malignancy risk factor both in the general population and in liver transplant recipients, smoking in combination with immunosuppression is presumed to be the main risk factor for transplant-related carcinomas. Several authors have suggested that a longer duration of immunosuppressive treatment or a stronger immunosuppression could be related to a higher risk of malignancy. However, the Spanish researchers failed to find such an association. Rather, they suggest that smoking after transplant which increases the risk, and smoking cessation following transplant surgery which decreases the risk, are more significant indicators.

"Smoking is related to some of the most frequent causes of post-transplant malignancy," says study leader Dr. J. Ignacio Herrero of the Clínica Universidad de Navarra in Pamplona, Spain. "We investigated whether the risks of developing malignancies was different in patients who ceased smoking than in patients who maintained smoking after transplantation." Risk factors of lung, head and neck, esophagus, kidney and urinary tract (other than prostate) cancers after liver transplantation were examined in the present study.

The research team introduced a screening protocol, according to the risk of neoplasia, related to smoking for every patient in the study. The patient population consisted of 339 liver transplant recipients receiving their first liver transplantation between April of 1990 and December of 2009 who had a post-transplant survival greater than three months. Participants received cyclosporine- or tacrolimus-based immunosuppression. Risk factors for the development of smoking-related neoplasia were also studied in 135 patients who had a history of smoking, in order to explore if smoking withdrawal was associated with a lower risk of malignancy.

SRM risk factors examined were age, sex, alcohol abuse before liver transplantation, hepatitis C virus infection, hepatocellular carcinoma at transplantation, primary immunosuppression (cyclosporine or tacrolimus), history of rejection requiring high doses of steroids or antilymphocytic globulins in the first 3 months, number of immunosuppressive drugs at 3 months, and smoking history. A second analysis of risk factors for the development of SRM was performed only in smokers, focusing on active versus prior smoking history.

After a mean follow-up of 7.5 years, 26 patients were diagnosed with 29 smoking-related malignancies. Five and ten-year actuarial rates were 5% and 13%, respectively. In multivariate analysis, smoking and a higher age were independently associated to a higher risk of malignancy. In the subgroup of smokers, the variables related to a higher risk of malignancy were active smoking and a higher age.

"Smoking withdrawal after liver transplantation may have a protective effect against the development of neoplasia," concluded Dr. Herrero. "As smoking is an important risk factor of malignancy, intervention programs, together with screening programs may help to reduce the rate of cancer-related mortality in liver transplant recipients."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Ignacio Herrero, Fernando Pardo, Delia D'Avola, Félix Alegre, Fernando Rotellar, Mercedes Iñarrairaegui, Pablo Martí, Bruno Sangro, Jorge Quiroga. Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: The effect of smoking withdrawal. Liver Transplantation, 2011; 17 (4): 402 DOI: 10.1002/lt.22247

Cite This Page:

Wiley-Blackwell. "Smoking in combination with immunosuppression poses greater risk for transplant-related carcinoma." ScienceDaily. ScienceDaily, 29 March 2011. <www.sciencedaily.com/releases/2011/03/110329095702.htm>.
Wiley-Blackwell. (2011, March 29). Smoking in combination with immunosuppression poses greater risk for transplant-related carcinoma. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2011/03/110329095702.htm
Wiley-Blackwell. "Smoking in combination with immunosuppression poses greater risk for transplant-related carcinoma." ScienceDaily. www.sciencedaily.com/releases/2011/03/110329095702.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins