Featured Research

from universities, journals, and other organizations

New drug target discovered for inflammatory bowel disease: Cytokine (IL-23)

Date:
March 31, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
A new discovery raises hope that new treatments for illnesses like Crohn's disease and ulcerative colitis are on the horizon. That's because they've identified IL-23, a cytokine used by the immune system to ward off disease, as a major contributor to the inflammation that is the hallmark of these illnesses.

A new discovery published in the April 2001 issue of Journal of Leukocyte Biology raises hope that new treatments for illnesses like Crohn's disease and ulcerative colitis are on the horizon. That's because they've identified IL-23, a cytokine used by the immune system to ward off disease, as a major contributor to the inflammation that is the hallmark of these illnesses.

Related Articles


With this information, it is now possible to develop new treatments that stop or reduce the damaging effects of IL-23, potentially bringing relief to millions of people with inflammatory bowel disease (IBD) and possibly other inflammatory illnesses as well.

"Our studies highlight the pathogenic role of IL-23 in the induction of mucosal injury in the gut," said Zhanju Liu, M.D., Ph.D., a researcher involved in the work from the Department of Gastroenterology at The Shanghai Tenth People's Hospital at Tongji University in Shanghai, China. "Moreover, our work also provides a novel approach in the management of IBD and some autoimmune diseases."

To make this discovery, Liu and colleagues analyzed IL-23 expression in intestinal mucosa using laboratory techniques that amplify and simultaneously quantify a specific DNA molecule, allowing for both detection and quantification of one or more specific sequences in a DNA sample. IL-23R expression was detected in a variety of cells from peripheral blood and intestinal mucosa of IBD patients, suggesting that IL-23 plays an important role in the induction of proinflammatory cytokine secretion as well as different types of immune cells including recently discovered Th17 helper T cells that are often important in inflammatory diseases.

"This research is important because it helps us better understand why people develop IBD, and defines one of the key pathways driving the excessive inflammation," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Even more important, however, is that this study moves us a step closer to new treatments for these illnesses by targeting IL-23 and related proteins."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Z. Liu, P. K. Yadav, X. Xu, J. Su, C. Chen, M. Tang, H. Lin, J. Yu, J. Qian, P.-C. Yang, X. Wang. The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity. Journal of Leukocyte Biology, 2011; DOI: 10.1189/jlb.0810456

Cite This Page:

Federation of American Societies for Experimental Biology. "New drug target discovered for inflammatory bowel disease: Cytokine (IL-23)." ScienceDaily. ScienceDaily, 31 March 2011. <www.sciencedaily.com/releases/2011/03/110331114844.htm>.
Federation of American Societies for Experimental Biology. (2011, March 31). New drug target discovered for inflammatory bowel disease: Cytokine (IL-23). ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/03/110331114844.htm
Federation of American Societies for Experimental Biology. "New drug target discovered for inflammatory bowel disease: Cytokine (IL-23)." ScienceDaily. www.sciencedaily.com/releases/2011/03/110331114844.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins