Featured Research

from universities, journals, and other organizations

Genetic defect suggests high blood pressure may come from mother

Date:
April 1, 2011
Source:
American Heart Association
Summary:
A mitochondrial defect inherited from mothers is linked to high blood pressure in one Chinese family. The finding may provide new insights into maternally transmitted hypertension.

A specific genetic defect in one Chinese family shows that high blood pressure was inherited from the female parent, researchers report in Circulation Research: Journal of the American Heart Association.

The defect results from a point mutation -- the substitution of a single DNA "base" for another during replication -- in the genes of a tiny cellular organ called the mitochondria, which generates a cell's energy. When reproductive cells come together to form an embryo, the mitochondrial DNA from the mother cell is passed on to the offspring. Evidence has suggested a mother-child inheritance link for high blood pressure due to mitochondrial inheritance.

The Chinese-led group, which also included researchers from the Cincinnati Children's Hospital Medical Center and the Medical University of Vienna in Austria, provides clinical, genetic, molecular and biochemical evidence that a mitochondrial mutation designated tRNAIle 4263A>G is associated with inherited high blood pressure. The DNA substitution researchers discovered is an adenine-to-guanine switch at position 4263 on the mitochondrial genome (4263A>G).

Geneticists identified a large family from northern China in which 15 of 27 members who descended from the same female ancestor had blood pressures above 140/90 mmHg even after treatment. Only seven of 81 non-maternal relatives had high blood pressure.

Researchers compared the family members with 342 Chinese residents of the same northern area to confirm a maternal link. Analysis of the mitochondrial genome of the maternal relatives and other tests revealed the site of the hypertension-related mutation and showed that it impairs the mitochondrial respiration chain, which increases levels of a reactive oxygen species (i.e., free radicals).

The findings show that inherited mitochondrial dysfunction is involved in high blood pressure and may provide new insights into maternally transmitted hypertension, researchers said.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Wang, R. Li, A. Fettermann, Z. Li, Y. Qian, Y. Liu, X. Wang, A. Zhou, J. Q. Mo, L. Yang, P. Jiang, A. Taschner, W. Rossmanith, M.-X. Guan. Maternally Inherited Essential Hypertension Is Associated With the Novel 4263A>G Mutation in the Mitochondrial tRNAIle Gene in a Large Han Chinese Family. Circulation Research, 2011; 108 (7): 862 DOI: 10.1161/CIRCRESAHA.110.231811

Cite This Page:

American Heart Association. "Genetic defect suggests high blood pressure may come from mother." ScienceDaily. ScienceDaily, 1 April 2011. <www.sciencedaily.com/releases/2011/03/110331163508.htm>.
American Heart Association. (2011, April 1). Genetic defect suggests high blood pressure may come from mother. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/03/110331163508.htm
American Heart Association. "Genetic defect suggests high blood pressure may come from mother." ScienceDaily. www.sciencedaily.com/releases/2011/03/110331163508.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins